Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 8/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | TTR | P02766 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CCNC | P24863 | 1/20 | 0.41 |
| ▸ | CDK8 | P49336 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8305022 | 1.00 | TBXAS1 (0.49) | TBXAS1PTGS2CYP3A4TTRDPP4 | |
| SCHEMBL8305030 | 1.00 | TBXAS1 (0.49) | TBXAS1PTGS2CYP3A4TTRDPP4 | |
| SCHEMBL8307857 | 0.92 | TBXAS1 (0.56) | TBXAS1PTGS2CYP3A4TTRDPP4 | |
| SCHEMBL8310505 | 0.92 | TBXAS1 (0.56) | TBXAS1PTGS2CYP3A4TTRDPP4 | |
| SCHEMBL8307861 | 0.92 | TBXAS1 (0.56) | TBXAS1PTGS2CYP3A4TTRDPP4 | |
| SCHEMBL8311436 | 0.85 | TBXAS1 (0.51) | TBXAS1PTGS2CYP3A4TTRDPP4 | |
| SCHEMBL8311433 | 0.85 | TBXAS1 (0.51) | TBXAS1PTGS2CYP3A4TTRDPP4 | |
| SCHEMBL11066167 | 0.82 | TBXAS1 (0.68) | TBXAS1CYP3A4TTRDPP4CA12 | |
| SCHEMBL10752973 | 0.82 | TBXAS1 (0.68) | TBXAS1CYP3A4TTRDPP4CA12 | |
| SCHEMBL8308473 | 0.82 | TBXAS1 (0.48) | TBXAS1PTGS2CYP3A4POLBCCNC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0579618-B1 | PYRIDINE- AND IMIDAZOLE-DERIVED AGENTS FOR CARDIOVASCULAR DISEASES | PFIZER LTD (GB) | 1999-10-13 | — | — | EP | disclosed |
| US-5705523-A | THROMBOXANE A2 SYNTHETASE INHIBITORS | PFIZER INC. (US) | 1998-01-06 | — | — | US | disclosed |
| US-5457118-A | Pyridine derived agents for cardiovascular diseases | PFIZER INC. (US) | 1995-10-10 | — | — | US | disclosed |
| EP-0579618-A1 | PYRIDINE- AND IMIDAZOLE-DERIVED AGENTS FOR CARDIOVASCULAR DISEASES | Pfizer Limited (GB) | 1994-01-26 | — | — | EP | disclosed |
| WO-1992017451-A1 | PYRIDINE- AND IMIDAZOLE-DERIVED AGENTS FOR CARDIOVASCULAR DISEASES | PFIZER LIMITED (GB) | 1992-10-15 | — | — | WO | disclosed |