Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 13/20 | 0.48 |
| ▸ | RAF1 | P04049 | 3/20 | 0.46 |
| ▸ | BRAF | P15056 | 3/20 | 0.46 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | CASP3 | P42574 | 1/20 | 0.45 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.45 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.45 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.45 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8308099 | 0.85 | NPC1 (0.49) | EGFRERBB2HPGDLCK | |
| SCHEMBL8308835 | 0.84 | HDAC3 (0.52) | EGFRERBB2 | |
| SCHEMBL8307434 | 0.84 | EGFR (0.53) | EGFRRAF1BRAFERBB2ALK | |
| Hydrochloric Acid SCHEMBL8306555 | 0.82 | HDAC3 (0.50) | EGFRERBB2 | |
| SCHEMBL7242341 | 0.79 | EGFR (0.53) | EGFRERBB2 | |
| SCHEMBL8615382 | 0.78 | MAPK13 (0.40) | BRAFHPGDCASP3SENP7SENP6 | |
| Hydrochloric Acid SCHEMBL6186793 | 0.75 | EGFR (0.67) | EGFRERBB2 | |
| SCHEMBL7240463 | 0.75 | EGFR (0.55) | EGFRBRAFERBB2 | |
| SCHEMBL7235423 | 0.75 | EGFR (0.63) | EGFRERBB2 | |
| SCHEMBL641359 | 0.74 | EGFR (0.75) | EGFRRAF1BRAFERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0790986-B1 | ANILINE DERIVATIVES | ZENECA LTD (GB) | 1999-01-20 | — | — | EP | disclosed |
| EP-0790986-A1 | ANILINE DERIVATIVES | ZENECA LIMITED (GB) | 1997-08-27 | — | — | EP | disclosed |
| WO-1996015118-A1 | ANILINE DERIVATIVES | ZENECA LIMITED (GB) | 1996-05-23 | — | — | WO | disclosed |