Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.46 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.46 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.44 |
| ▸ | CASP6 | P55212 | 1/20 | 0.43 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.43 |
| ▸ | CDK7 | P50613 | 1/20 | 0.43 |
| ▸ | ALPL | P05186 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL627865 | 0.84 | ABCG2 (0.57) | HDAC6KMT2AMAPTSMN1; SMN2FGFR1 | |
| SCHEMBL628824 | 0.81 | SMN1; SMN2 (0.56) | KMT2ASMN1; SMN2MEN1ALDH1A1CYP3A4 | |
| SCHEMBL627825 | 0.81 | KMT2A (0.52) | HDAC6KMT2AMAPTSMN1; SMN2MEN1 | |
| SCHEMBL626056 | 0.78 | MEN1 (0.54) | KMT2AMAPTSMN1; SMN2MEN1POLB | |
| SCHEMBL627899 | 0.78 | FGFR1 (0.65) | HDAC6IRAK4FGFR1FGFR2FGFR3 | |
| SCHEMBL31040239 | 0.78 | FGFR1 (0.65) | HDAC6IRAK4FGFR1FGFR2FGFR3 | |
| SCHEMBL622021 | 0.76 | FLT3 (0.59) | HDAC6FGFR1FGFR2FGFR3CDK2 | |
| SCHEMBL628194 | 0.76 | HDAC6 (0.64) | HDAC6KMT2AMAPTFGFR1FGFR2 | |
| SCHEMBL5672888 | 0.76 | POLB (0.51) | HDAC6KMT2AMAPTFGFR1FGFR2 | |
| SCHEMBL4008807 | 0.75 | CDK2 (0.70) | HDAC6KMT2AIRAK4MAPTFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934068-A1 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998009630-A1 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-03-12 | — | — | WO | disclosed |