Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 1/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8301717 | 0.90 | AHR (0.41) | AHRKEAP1PDPK1HTR2AHTR2C | |
| SCHEMBL2261191 | 0.84 | AHR (0.47) | AHRKEAP1PDPK1BACE1 | |
| SCHEMBL1452618 | 0.77 | AHR (0.47) | AHRKEAP1PDPK1HTR2AHTR2C | |
| SCHEMBL27758138 | 0.77 | AHR (0.47) | AHRKEAP1PDPK1HTR2AHTR2C | |
| SCHEMBL1253323 | 0.77 | AHR (0.47) | AHRKEAP1PDPK1HTR2A | |
| SCHEMBL2262208 | 0.77 | AHR (0.47) | AHRKEAP1PDPK1HTR2AHTR2C | |
| SCHEMBL34463040 | 0.77 | AHR (0.47) | AHRKEAP1PDPK1HTR2A | |
| SCHEMBL6029507 | 0.74 | AHR (0.44) | AHRKEAP1PDPK1HTR2AHTR2C | |
| SCHEMBL3790923 | 0.74 | AHR (0.44) | AHRKEAP1PDPK1HTR2AHTR2C | |
| SCHEMBL31561732 | 0.74 | AHR (0.44) | AHRKEAP1PDPK1HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0469833-B1 | N-Benzyl-Indoles, processes for their preparation and pharmaceutical compositions containing them | LILLY CO ELI (GB) | 1999-09-08 | — | — | EP | disclosed |
| CN-1040108-C | Pharmaceutical compounds | LILLY INDUSTRIES LTD (GB) | 1998-10-07 | — | — | CN | disclosed |
| US-5622969-A | ADMINISTERING TO HUMAN OR ANIMAL SUFFERING FROM ALLERGIC REACTION OF PULMONARY SYSTEM AND OTHER INFLAMMATORY DISORDERS | ELI LILLY AND COMPANY (US) | 1997-04-22 | — | — | US | disclosed |
| US-5569764-A | USEFUL FOR TREATING ALLERGIC REACTIONS OF PULMONARY SYSTEM, ALLERGIC SKIN DISEASES, RHEUMATIC FEVER, CYSTIC FIBROSIS, AND VASCULAR DISEASES | ELI LILLY AND COMPANY (US) | 1996-10-29 | — | — | US | disclosed |
| US-5486612-A | FOR TREATING DISEASES WHICH LEUKOTRIENES MEDIATE | ELI LILLY AND COMPANY (US) | 1996-01-23 | — | — | US | disclosed |
| EP-0658554-A1 | N-benzyl dihydroindole LTD4 antagonists | ELI LILLY AND COMPANY (US) | 1995-06-21 | — | — | EP | disclosed |
| US-5281593-A | Pharmaceuticals | LILLY INDUSTRIES LIMITED (GB) | 1994-01-25 | — | — | US | disclosed |
| CN-1061413-A | Medicinal compound | LILLY INDUSTRIES LTD (GB) | 1992-05-27 | — | — | CN | disclosed |
| EP-0469833-A1 | N-Benzyl-Indoles, processes for their preparation and pharmaceutical compositions containing them | LILLY INDUSTRIES LIMITED (GB) | 1992-02-05 | — | — | EP | disclosed |