Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MPO | P05164 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8306159 | 0.90 | AHR (0.43) | AHRKEAP1HTR2AHTR2CPDPK1 | |
| SCHEMBL2261191 | 0.81 | AHR (0.47) | AHRKEAP1PDPK1BACE1 | |
| SCHEMBL31561732 | 0.78 | AHR (0.44) | AHRKEAP1HTR2AHTR2CPDPK1 | |
| SCHEMBL3790923 | 0.78 | AHR (0.44) | AHRKEAP1HTR2AHTR2CPDPK1 | |
| SCHEMBL28362482 | 0.78 | AHR (0.44) | AHRKEAP1HTR2AHTR2CPDPK1 | |
| SCHEMBL6029507 | 0.78 | AHR (0.44) | AHRKEAP1HTR2AHTR2CPDPK1 | |
| SCHEMBL31561738 | 0.78 | AHR (0.44) | AHRKEAP1HTR2AHTR2CPDPK1 | |
| SCHEMBL9248977 | 0.77 | AHR (0.43) | AHRKEAP1HTR2AHTR2C | |
| SCHEMBL2260654 | 0.77 | MPO (0.46) | AHRMPOSLC6A4KEAP1HTR2A | |
| SCHEMBL9026320 | 0.75 | AHR (0.42) | AHRKEAP1HTR2AHTR2CPDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0469833-B1 | N-Benzyl-Indoles, processes for their preparation and pharmaceutical compositions containing them | LILLY CO ELI (GB) | 1999-09-08 | — | — | EP | disclosed |
| US-5281593-A | Pharmaceuticals | LILLY INDUSTRIES LIMITED (GB) | 1994-01-25 | — | — | US | disclosed |
| EP-0469833-A1 | N-Benzyl-Indoles, processes for their preparation and pharmaceutical compositions containing them | LILLY INDUSTRIES LIMITED (GB) | 1992-02-05 | — | — | EP | disclosed |