Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 9/20 | 0.48 |
| ▸ | CYP11B2 | P19099 | 9/20 | 0.48 |
| ▸ | FNTA | P49354 | 5/20 | 0.46 |
| ▸ | FNTB | P49356 | 5/20 | 0.46 |
| ▸ | CDC25A | P30304 | 1/20 | 0.42 |
| ▸ | CDC25B | P30305 | 1/20 | 0.42 |
| ▸ | CDC25C | P30307 | 1/20 | 0.42 |
| ▸ | PGGT1B | P53609 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8310070 | 0.91 | CYP11B1 (0.55) | CYP11B1CYP11B2FNTAFNTBCDC25A | |
| Trifluoroacetic Acid SCHEMBL8309328 | 0.85 | CYP11B1 (0.57) | CYP11B1CYP11B2FNTAFNTBPGGT1B | |
| Trifluoroacetic Acid SCHEMBL7484728 | 0.76 | CYP11B1 (0.59) | CYP11B1CYP11B2FNTAFNTBPGGT1B | |
| Trifluoroacetic Acid SCHEMBL7484732 | 0.76 | CYP11B1 (0.61) | CYP11B1CYP11B2FNTAFNTBPGGT1B | |
| SCHEMBL5891741 | 0.75 | CYP11B1 (0.58) | CYP11B1CYP11B2FNTAFNTBPGGT1B | |
| SCHEMBL5891899 | 0.75 | CYP11B1 (0.68) | CYP11B1CYP11B2FNTAFNTBPGGT1B | |
| Hydrochloric Acid SCHEMBL8227737 | 0.74 | CYP11B1 (0.57) | CYP11B1CYP11B2FNTAFNTBPGGT1B | |
| Hydrochloric Acid SCHEMBL8188315 | 0.74 | CYP11B1 (0.67) | CYP11B1CYP11B2FNTAFNTBPGGT1B | |
| SCHEMBL5891934 | 0.73 | CYP11B1 (0.64) | CYP11B1CYP11B2FNTAFNTBPGGT1B | |
| SCHEMBL8306479 | 0.72 | CYP11B1 (0.57) | CYP11B1CYP11B2FNTAFNTB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5939557-A | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 1999-08-17 | — | — | US | disclosed |
| EP-0891343-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1999-01-20 | — | — | EP | disclosed |
| WO-1997036886-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1997-10-09 | — | — | WO | disclosed |