Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 15/20 | 0.78 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8309265 | 0.88 | TBXAS1 (1.00) | TBXAS1 | |
| SCHEMBL8309354 | 0.87 | TBXAS1 (1.00) | TBXAS1 | |
| SCHEMBL8309319 | 0.86 | TBXAS1 (0.59) | TBXAS1HPGDMAPK1USP2ALDH1A1 | |
| SCHEMBL8309257 | 0.79 | TBXAS1 (0.77) | TBXAS1 | |
| SCHEMBL8306419 | 0.76 | TBXAS1 (1.00) | TBXAS1 | |
| SCHEMBL8305062 | 0.76 | TBXAS1 (0.79) | TBXAS1 | |
| SCHEMBL8307370 | 0.75 | TBXAS1 (0.77) | TBXAS1 | |
| SCHEMBL8309043 | 0.74 | TBXAS1 (0.77) | TBXAS1 | |
| SCHEMBL8305168 | 0.69 | TBXAS1 (0.78) | TBXAS1 | |
| SCHEMBL9178744 | 0.68 | TBXAS1 (1.00) | TBXAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0579618-B1 | PYRIDINE- AND IMIDAZOLE-DERIVED AGENTS FOR CARDIOVASCULAR DISEASES | PFIZER LTD (GB) | 1999-10-13 | — | — | EP | disclosed |
| US-5705523-A | THROMBOXANE A2 SYNTHETASE INHIBITORS | PFIZER INC. (US) | 1998-01-06 | — | — | US | disclosed |
| US-5457118-A | Pyridine derived agents for cardiovascular diseases | PFIZER INC. (US) | 1995-10-10 | — | — | US | disclosed |