Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 17/20 | 0.90 |
| ▸ | PIM1 | P11309 | 1/20 | 0.76 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.76 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | LYN | P07948 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
| ▸ | FLT4 | P35916 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | CLK2 | P49760 | 1/20 | 0.39 |
| ▸ | BLK | P51451 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.39 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.39 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.39 |
| ▸ | MELK | Q14680 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL62121 | 0.95 | PARP1 (1.00) | PARP1PIM1CSNK1DKMT2A | |
| SCHEMBL61598 | 0.92 | PARP1 (0.82) | PARP1PIM1CSNK1DKMT2A | |
| SCHEMBL52020 | 0.91 | PARP1 (0.79) | PARP1PIM1CSNK1D | |
| SCHEMBL10035767 | 0.87 | PIM1 (0.82) | PARP1PIM1CSNK1DKMT2A | |
| SCHEMBL61589 | 0.87 | PIM1 (0.85) | PARP1PIM1CSNK1DKMT2A | |
| SCHEMBL29496129 | 0.86 | PIM1 (1.00) | PARP1PIM1CSNK1D | |
| SCHEMBL51064 | 0.86 | PIM1 (1.00) | PARP1PIM1CSNK1D | |
| SCHEMBL1319786 | 0.86 | PIM1 (0.84) | PARP1PIM1CSNK1D | |
| SCHEMBL51776 | 0.85 | PIM1 (0.82) | PARP1PIM1CSNK1DKMT2A | |
| SCHEMBL51663 | 0.85 | PIM1 (0.85) | PARP1PIM1CSNK1DKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004105700-A2 | COMPOUNDS, METHODS AND PHARMACEUTICAL COMPOSITIONS FOR INHIBITING PARP | GUILDFORD PHARMACEUTICALS, INC. (US) | 2004-12-09 | — | — | WO | disclosed |