SCHEMBL8306792

SCHEMBL8306792

O=C1O[C@@H](CO)CN1c1ccc(N2CCSCC2)c(F)c1

nearest known ligand 0.73

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
MAOB P27338 9/20 0.73
MAOA P21397 3/20 0.73
F10 P00742 6/20 0.66
CALML3 P27482 6/20 0.58
LMNA P02545 1/20 0.57
PTGS1 P23219 1/20 0.57
SDHA P31040 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8306793 1.00 MAOB (0.73) MAOBMAOAF10CALML3LMNA
SCHEMBL18396775 0.96 MAOB (0.68) MAOBMAOAF10CALML3LMNA
SCHEMBL18396777 0.96 MAOB (0.68) MAOBMAOAF10CALML3LMNA
SCHEMBL8305130 0.93 MAOB (0.64) MAOBMAOAF10CALML3LMNA
SCHEMBL18396744 0.93 MAOB (0.64) MAOBMAOAF10CALML3LMNA
SCHEMBL18396747 0.93 MAOB (0.64) MAOBMAOAF10CALML3LMNA
SCHEMBL8305126 0.93 MAOB (0.64) MAOBMAOAF10CALML3LMNA
SCHEMBL28109794 0.90 CALML3 (0.65) MAOBMAOAF10CALML3LMNA
SCHEMBL77866 0.89 MAOB (0.70) MAOBMAOAF10CALML3LMNA
SCHEMBL3519368 0.89 MAOB (0.70) MAOBMAOAF10CALML3LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3932917-A2 SUBSTITUTED PHENYLOXAZOLIDINONES FOR ANTIMICROBIAL THERAPY The Global Alliance for TB Drug Development, Inc. (US) 2022-01-05 EP disclosed
US-20200148651-A1 SUBSTITUTED PHENYLOXAZOLIDINONES FOR ANTIMICROBIAL THERAPY GLOBAL ALLIANCE FOR TB DRUG DEVELOPMENT INC (US) 2020-05-14 US disclosed
US-10550092-B2 Substituted phenyloxazolidinones for antimicrobial therapy THE GLOBAL ALLIANCE FOR TB DRUG DEVELOPMENT, INC. (US) 2020-02-04 US disclosed
US-20180179168-A1 SUBSTITUTED PHENYLOXAZOLIDINONES FOR ANTIMICROBIAL THERAPY THE GLOBAL ALLIANCE FOR TB DRUG DEVELOPMENT, INC. 2018-06-28 US disclosed
WO-2017015106-A1 SUBSTITUTED PHENYLOXAZOLIDINONES FOR ANTIMICROBIAL THERAPY THE GLOBAL ALLIANCE FOR TB DRUG DEVELOPMENT, INC. (US) 2017-01-26 WO disclosed
EP-0717738-B1 SUBSTITUTED OXAZINE AND THIAZINE OXAZOLIDINONE ANTIMICROBIALS UPJOHN CO (US) 1999-10-20 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180179168-A1 SUBSTITUTED PHENYLOXAZOLIDINONES FOR ANTIMICROBIAL THERAPY THPO, TBCD, OXA1L MAOB 1541/4885MAOA 2234/4885F10 4810/4885
US-20200148651-A1 SUBSTITUTED PHENYLOXAZOLIDINONES FOR ANTIMICROBIAL THERAPY THPO, TBCD, OXA1L MAOB 1541/4885MAOA 2234/4885F10 4810/4885
US-10550092-B2 Substituted phenyloxazolidinones for antimicrobial therapy THPO, TBCD, OXA1L MAOB 1541/4885MAOA 2234/4885F10 4810/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.