Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.81 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.81 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.81 |
| ▸ | MAPT | P10636 | 2/20 | 0.81 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.81 |
| ▸ | NPC1 | O15118 | 12/20 | 0.72 |
| ▸ | RAB9A | P51151 | 12/20 | 0.72 |
| ▸ | MEN1 | O00255 | 5/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.71 |
| ▸ | PKM | P14618 | 3/20 | 0.62 |
| ▸ | MAOB | P27338 | 1/20 | 0.62 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.62 |
| ▸ | TP53 | P04637 | 2/20 | 0.60 |
| ▸ | SCD | O00767 | 1/20 | 0.60 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.60 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16562030 | 0.84 | NPC1 (1.00) | SMN1; SMN2KMT2AIRAK4MAPTMCL1 | |
| SCHEMBL3597174 | 0.83 | IRAK4 (1.00) | SMN1; SMN2KMT2AIRAK4MAPTMCL1 | |
| SCHEMBL9963858 | 0.82 | RAB9A (0.76) | SMN1; SMN2KMT2AMAPTNPC1RAB9A | |
| SCHEMBL11703736 | 0.82 | NPC1 (0.91) | SMN1; SMN2KMT2AMAPTNPC1RAB9A | |
| SCHEMBL11703862 | 0.81 | NPC1 (0.83) | SMN1; SMN2KMT2AIRAK4NPC1RAB9A | |
| SCHEMBL25956571 | 0.80 | IRAK4 (0.81) | SMN1; SMN2KMT2AIRAK4MAPTMCL1 | |
| SCHEMBL25956570 | 0.80 | IRAK4 (0.81) | SMN1; SMN2KMT2AIRAK4MAPTMCL1 | |
| SCHEMBL11705464 | 0.80 | RAB9A (0.72) | SMN1; SMN2KMT2AMAPTNPC1RAB9A | |
| SCHEMBL3926899 | 0.78 | NPC1 (1.00) | SMN1; SMN2KMT2AIRAK4MAPTNPC1 | |
| SCHEMBL11719912 | 0.78 | NPC1 (0.74) | SMN1; SMN2KMT2AMAPTMCL1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934068-A1 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998009630-A1 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-03-12 | — | — | WO | disclosed |