Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.45 |
| ▸ | DHFR | P00374 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.42 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27660656 | 0.80 | MEN1 (0.45) | ALDH1A1KDM4EHPGDADORA2AADORA1 | |
| SCHEMBL10262765 | 0.78 | PSMB5 (0.47) | ALDH1A1HSD17B10KDM4EHPGDADORA2A | |
| SCHEMBL2174430 | 0.78 | FGFR1 (0.49) | ALDH1A1HSD17B10KDM4EADORA2AADORA1 | |
| SCHEMBL5360517 | 0.77 | SYK (0.45) | ALDH1A1KDM4EHPGDADORA1KMT2A | |
| SCHEMBL24156309 | 0.76 | MEN1 (0.47) | ALDH1A1HSD17B10ADORA1KMT2AMEN1 | |
| SCHEMBL29972990 | 0.75 | KDM4E (0.45) | ALDH1A1HSD17B10KDM4EHPGDADORA2A | |
| SCHEMBL8305228 | 0.75 | DHODH (0.54) | ALDH1A1KDM4EADORA1KMT2AMEN1 | |
| SCHEMBL3180674 | 0.75 | FGFR1 (0.46) | ALDH1A1HSD17B10KDM4EHPGDADORA2A | |
| SCHEMBL1901873 | 0.75 | KDM4E (0.45) | ALDH1A1HSD17B10KDM4EHPGDADORA2A | |
| SCHEMBL610009 | 0.75 | PIN1 (0.49) | ALDH1A1HSD17B10KDM4EMAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5872136-A | Arylheteroaryl inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 1999-02-16 | — | — | US | disclosed |
| EP-0891361-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1999-01-20 | — | — | EP | disclosed |
| WO-1997036901-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1997-10-09 | — | — | WO | disclosed |