Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.42 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.42 |
| ▸ | TDO2 | P48775 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.41 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8306873 | 0.80 | ALDH1A1 (0.53) | MEN1KMT2ARAB9AKDM4ENPC1 | |
| SCHEMBL5776315 | 0.77 | MAPK13 (0.41) | MEN1KMT2ARAB9AKDM4ENPC1 | |
| SCHEMBL22290190 | 0.77 | KDM4E (0.39) | MEN1KMT2ARAB9AKDM4ENPC1 | |
| SCHEMBL15058043 | 0.75 | DHODH (0.48) | TGFBR1ADORA1ADORA2AMAP4K4MAPK14 | |
| SCHEMBL2470048 | 0.74 | DHODH (0.47) | TGFBR1ADORA1ADORA2AMAP4K4MAPK14 | |
| SCHEMBL4499287 | 0.73 | NOS3 (0.47) | MEN1KMT2ARAB9AKDM4ENPC1 | |
| SCHEMBL16277505 | 0.73 | ALOX15 (0.44) | MEN1KMT2AKDM4EMAPTSMN1; SMN2 | |
| SCHEMBL13309126 | 0.73 | ADORA2A (0.39) | MEN1KMT2ARAB9AKDM4ENPC1 | |
| Lithium Ion SCHEMBL2470047 | 0.73 | DHODH (0.41) | RAB9ANPC1SMN1; SMN2TGFBR1ADORA1 | |
| SCHEMBL2472320 | 0.72 | SLC6A4 (0.51) | RAB9AKDM4ENPC1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1956971-A | Novel fused heterocycles and application thereof | ASTRAZENECA AB (SE) | 2007-05-02 | — | — | CN | disclosed |