Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 11/20 | 0.65 |
| ▸ | FLT1 | P17948 | 7/20 | 0.65 |
| ▸ | EGFR | P00533 | 9/20 | 0.64 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.64 |
| ▸ | RET | P07949 | 5/20 | 0.62 |
| ▸ | KIF5B | P33176 | 4/20 | 0.62 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.62 |
| ▸ | FLT4 | P35916 | 2/20 | 0.61 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.61 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.58 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.54 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.54 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.54 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7455632 | 0.89 | FLT1 (0.77) | KDRFLT1EGFRFGFR1FLT4 | |
| SCHEMBL8306485 | 0.85 | EGFR (0.53) | KDRFLT1EGFRFGFR1RET | |
| SCHEMBL8305114 | 0.84 | EGFR (0.49) | KDRFLT1EGFRERBB2ERBB4 | |
| SCHEMBL8308072 | 0.83 | EGFR (0.49) | KDRFLT1EGFRFGFR1ERBB2 | |
| SCHEMBL18158255 | 0.83 | EGFR (0.73) | KDRFLT1EGFRFGFR1RET | |
| SCHEMBL8309481 | 0.82 | EGFR (0.50) | KDRFLT1EGFRFGFR1ERBB2 | |
| SCHEMBL8308821 | 0.82 | EGFR (0.80) | KDRFLT1EGFRFGFR1RET | |
| SCHEMBL9911563 | 0.81 | EGFR (0.55) | KDRFLT1EGFRRETERBB2 | |
| SCHEMBL9910687 | 0.81 | EGFR (0.57) | KDREGFRRETKIF5BERBB2 | |
| SCHEMBL8309434 | 0.81 | EGFR (0.66) | KDREGFRERBB2ERBB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0790986-B1 | ANILINE DERIVATIVES | ZENECA LTD (GB) | 1999-01-20 | — | — | EP | claimed |
| EP-0790986-A1 | ANILINE DERIVATIVES | ZENECA LIMITED (GB) | 1997-08-27 | — | — | EP | claimed |
| WO-1996015118-A1 | ANILINE DERIVATIVES | ZENECA LIMITED (GB) | 1996-05-23 | — | — | WO | claimed |
| EP-0790986-B1 | ANILINE DERIVATIVES | ZENECA LTD (GB) | 1999-01-20 | — | — | EP | disclosed |
| EP-0790986-A1 | ANILINE DERIVATIVES | ZENECA LIMITED (GB) | 1997-08-27 | — | — | EP | disclosed |
| WO-1996015118-A1 | ANILINE DERIVATIVES | ZENECA LIMITED (GB) | 1996-05-23 | — | — | WO | disclosed |