Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 9/20 | 0.50 |
| ▸ | ERBB2 | P04626 | 7/20 | 0.50 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.50 |
| ▸ | LCK | P06239 | 1/20 | 0.50 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | CDK9 | P50750 | 1/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.46 |
| ▸ | GCK | P35557 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | RAF1 | P04049 | 3/20 | 0.43 |
| ▸ | BRAF | P15056 | 3/20 | 0.43 |
| ▸ | FLT1 | P17948 | 2/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8309434 | 0.88 | EGFR (0.66) | EGFRERBB2ERBB4LCKCCNT1 | |
| SCHEMBL8306485 | 0.87 | EGFR (0.53) | EGFRERBB2ERBB4LCKCCNT1 | |
| SCHEMBL8305114 | 0.84 | EGFR (0.49) | EGFRERBB2ERBB4LCKCCNT1 | |
| SCHEMBL8306919 | 0.82 | KDR (0.65) | EGFRERBB2ERBB4KDRFLT1 | |
| SCHEMBL8309848 | 0.82 | ALDH1A1 (0.57) | EGFRERBB2ERBB4LCKCCNT1 | |
| SCHEMBL8308072 | 0.81 | EGFR (0.49) | EGFRERBB2ERBB4LCKCCNT1 | |
| SCHEMBL8307584 | 0.80 | ERBB2 (0.68) | EGFRERBB2ERBB4LCK | |
| SCHEMBL8782984 | 0.79 | DYRK1A (0.53) | EGFRERBB2ERBB4LCKCCNT1 | |
| SCHEMBL8616965 | 0.79 | ERBB2 (0.48) | EGFRERBB2ERBB4LCKDYRK1A | |
| SCHEMBL8443996 | 0.78 | CYP3A4 (0.54) | EGFRERBB2ERBB4LCKCCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0790986-B1 | ANILINE DERIVATIVES | ZENECA LTD (GB) | 1999-01-20 | — | — | EP | disclosed |
| US-5821246-A | USEFUL AS TYROSINE KINASE INHIBITORS AND FOR THE TREATMENT OF PROLIFERATIVE DISEASES SUCH AS CANCER | ZENECA LIMITED (GB) | 1998-10-13 | — | — | US | disclosed |
| EP-0790986-A1 | ANILINE DERIVATIVES | ZENECA LIMITED (GB) | 1997-08-27 | — | — | EP | disclosed |
| WO-1996015118-A1 | ANILINE DERIVATIVES | ZENECA LIMITED (GB) | 1996-05-23 | — | — | WO | disclosed |