Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTAFR | P25105 | 3/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 8/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 7/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8483971 | 0.76 | PTAFR (0.36) | PTAFRSLC6A2SLC6A3SLC6A4CYP2D6 | |
| SCHEMBL8479446 | 0.73 | TACR1 (0.33) | — | |
| SCHEMBL8366455 | 0.72 | PTAFR (0.36) | PTAFRSLC6A2SLC6A3SLC6A4CYP2D6 | |
| SCHEMBL8478669 | 0.71 | PTAFR (0.39) | PTAFRSLC6A2SLC6A3SLC6A4CYP2D6 | |
| SCHEMBL8479038 | 0.70 | PTAFR (0.44) | PTAFRSLC6A2SLC6A3SLC6A4CYP2D6 | |
| SCHEMBL2155319 | 0.68 | PDE4A (0.56) | SLC6A2SLC6A3SLC6A4CYP2D6KCNH2 | |
| SCHEMBL8561220 | 0.68 | MEN1 (0.39) | PTAFRSLC6A2SLC6A3SLC6A4CYP2D6 | |
| SCHEMBL8366968 | 0.67 | PTAFR (0.39) | PTAFRSLC6A2SLC6A3SLC6A4CYP2D6 | |
| SCHEMBL8366957 | 0.66 | PTAFR (0.44) | PTAFRSLC6A2SLC6A3SLC6A4CYP2D6 | |
| SCHEMBL9272077 | 0.61 | SLC6A2 (0.50) | SLC6A2SLC6A3SLC6A4CYP2D6KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0777666-B1 | SUBSTITUTED PIPERIDINES USEFUL FOR THE TREATMENT OF ALLERGIC DISEASES | MERRELL PHARMA INC (US) | 1999-03-03 | — | — | EP | disclosed |
| US-5859029-A | TREATING SUBSTANCE P-DEPENDENT PATHOLOGICAL CONDITIONS | SANOFI (FR) | 1999-01-12 | — | — | US | disclosed |