Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 10/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 10/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | PTAFR | P25105 | 3/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.32 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.32 |
| ▸ | NAAA | Q02083 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8558084 | 0.78 | PTAFR (0.37) | MEN1KMT2APTAFRPDE4DKDM4C | |
| SCHEMBL8291780 | 0.71 | KCNH2 (0.48) | MEN1KMT2ASLC6A2SLC6A3SLC6A4 | |
| SCHEMBL8366968 | 0.69 | PTAFR (0.39) | SLC6A2SLC6A3SLC6A4CYP2D6KCNH2 | |
| SCHEMBL8478669 | 0.69 | PTAFR (0.39) | SLC6A2SLC6A3SLC6A4CYP2D6KCNH2 | |
| SCHEMBL8307213 | 0.68 | PTAFR (0.34) | SLC6A2SLC6A3SLC6A4CYP2D6KCNH2 | |
| SCHEMBL8564881 | 0.67 | PDE4A (0.38) | MEN1KMT2APDE4DKDM4CKCNA5 | |
| SCHEMBL7956526 | 0.67 | MEN1 (0.38) | MEN1KMT2ASLC6A2SLC6A3SLC6A4 | |
| SCHEMBL8702363 | 0.66 | MEN1 (0.37) | MEN1KMT2ASLC6A2SLC6A3SLC6A4 | |
| SCHEMBL4630820 | 0.65 | MEN1 (0.39) | MEN1KMT2ASLC6A2SLC6A3SLC6A4 | |
| SCHEMBL11148815 | 0.65 | MEN1 (0.45) | MEN1KMT2AKDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5807865-A | 3,3-disubstituted piperidine derivatives and their use as therapeutic agents | MERCK SHARP & DOHME LIMITED (GB) | 1998-09-15 | — | — | US | disclosed |