Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 2/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.40 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.38 |
| ▸ | GYS1 | P13807 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | PTPRC | P08575 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.33 |
| ▸ | EED | O75530 | 1/20 | 0.33 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.33 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.33 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11390274 | 0.83 | ABCG2 (0.50) | CHEK2CHEK1PKMTSHRABCG2 | |
| SCHEMBL8309663 | 0.83 | CHEK1 (0.41) | CHEK2CHEK1PKMTSHRABCG2 | |
| SCHEMBL7594061 | 0.80 | ABCG2 (0.55) | CHEK2CHEK1PKMTSHRABCG2 | |
| SCHEMBL28643377 | 0.79 | ALDH1A1 (0.47) | CHEK2CHEK1PKMTSHRABCG2 | |
| SCHEMBL4347210 | 0.79 | RIPK3 (0.56) | CHEK2CHEK1PKMTSHRABCG2 | |
| SCHEMBL6312116 | 0.78 | ABCG2 (0.48) | CHEK2CHEK1PKMTSHRABCG2 | |
| SCHEMBL962586 | 0.77 | CHEK1 (0.40) | CHEK2CHEK1PKMTSHRABCG2 | |
| SCHEMBL22493388 | 0.76 | CHEK2 (0.56) | CHEK2CHEK1PKMTSHRDHODH | |
| SCHEMBL1145483 | 0.72 | ABCG2 (0.50) | PKMTSHRABCG2GSK3BEED | |
| SCHEMBL14320997 | 0.72 | CHEK2 (0.47) | CHEK2CHEK1PKMTSHRABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0892795-A1 | PIPERIDINYLPYRAMIDINE DERIVATIVES | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1999-01-27 | — | — | EP | disclosed |
| WO-1997038992-A1 | PIPERIDINYLPYRAMIDINE DERIVATIVES | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1997-10-23 | — | — | WO | disclosed |