Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 3/20 | 0.78 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.71 |
| ▸ | MEN1 | O00255 | 11/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 11/20 | 0.71 |
| ▸ | MAPK1 | P28482 | 7/20 | 0.71 |
| ▸ | POLB | P06746 | 5/20 | 0.71 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.71 |
| ▸ | EP300 | Q09472 | 1/20 | 0.67 |
| ▸ | MAPT | P10636 | 7/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.65 |
| ▸ | RECQL | P46063 | 3/20 | 0.63 |
| ▸ | HPGD | P15428 | 1/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.62 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | MYC | P01106 | 1/20 | 0.60 |
| ▸ | MAX | P61244 | 1/20 | 0.60 |
| ▸ | ATM | Q13315 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8308291 | 1.00 | PDE4B (0.78) | PDE4BHSD17B3MEN1KMT2AMAPK1 | |
| SCHEMBL2370857 | 0.85 | PDE4B (0.78) | PDE4BMEN1KMT2AMAPK1POLB | |
| SCHEMBL29374482 | 0.85 | PDE4B (0.78) | PDE4BMEN1KMT2AMAPK1POLB | |
| SCHEMBL9393527 | 0.85 | PDE4B (0.78) | PDE4BMEN1KMT2AMAPK1POLB | |
| SCHEMBL19999083 | 0.84 | MEN1 (0.75) | PDE4BMEN1KMT2AMAPK1POLB | |
| SCHEMBL12008489 | 0.83 | FABP4 (0.81) | PDE4BMEN1KMT2AMAPK1POLB | |
| SCHEMBL9331154 | 0.82 | PDE4B (0.73) | PDE4BHSD17B3MEN1KMT2AMAPK1 | |
| SCHEMBL9331160 | 0.82 | PDE4B (0.73) | PDE4BHSD17B3MEN1KMT2AMAPK1 | |
| SCHEMBL12008732 | 0.81 | CTNNB1 (0.85) | PDE4BMEN1KMT2AMAPK1POLB | |
| SCHEMBL8713783 | 0.81 | PDE4B (0.63) | PDE4BHSD17B3MEN1KMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0915090-A1 | Compounds useful as hypoglycemic agents and for treating Alzheimer's disease | ELI LILLY AND COMPANY (US) | 1999-05-12 | — | — | EP | disclosed |
| US-5731336-A | USING ARYL-SUBSTITUTED RHODAMINES | ELI LILLY AND COMPANY (US) | 1998-03-24 | — | — | US | disclosed |
| US-5716975-A | NONTOXIC RHODANINE DERIVATIVES; ANTIDIABETIC AGENTS, CATHEPSIN D INHIBITORS, B-AMYLOID PROTEIN REDUCTION | ELI LILLY AND COMPANY (US) | 1998-02-10 | — | — | US | disclosed |
| US-5661168-A | ADMINISTERING RHODANINE DERIVATIVES TO CONTROL DIABETES | ELI LILLY AND COMPANY (US) | 1997-08-26 | — | — | US | disclosed |
| WO-1996022772-A1 | METHOD FOR TREATING MULTIPLE SCLEROSIS | ELI LILLY AND COMPANY (US) | 1996-08-01 | — | — | WO | disclosed |
| EP-0722729-A2 | Aryl-substituted rhodanines for treating multiple sclerosis | ELI LILLY AND COMPANY (US) | 1996-07-24 | — | — | EP | disclosed |
| US-5523314-A | RHODANINE DERIVATIVES | ELI LILLY AND COMPANY (US) | 1996-06-04 | — | — | US | disclosed |
| EP-0587377-A2 | Thiazolidinone derivatives as hypoglycemic agents and for treating Alzheimer's disease | ELI LILLY AND COMPANY (US) | 1994-03-16 | — | — | EP | disclosed |