Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK2 | O43353 | 11/20 | 0.74 |
| ▸ | SRC | P12931 | 5/20 | 0.72 |
| ▸ | KDR | P35968 | 2/20 | 0.58 |
| ▸ | LCK | P06239 | 1/20 | 0.58 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | BRAF | P15056 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4261283 | 0.88 | RIPK2 (0.70) | RIPK2SRCKDRLCKTGFBR1 | |
| SCHEMBL4265907 | 0.88 | RIPK2 (0.61) | RIPK2SRCKDRLCKTGFBR1 | |
| SCHEMBL5618684 | 0.87 | RIPK2 (0.68) | RIPK2SRCKDRLCKTGFBR1 | |
| SCHEMBL8357880 | 0.87 | RIPK2 (0.72) | RIPK2SRCKDRLCKTGFBR1 | |
| SCHEMBL6646290 | 0.86 | RIPK2 (0.67) | RIPK2SRCKDRLCKTGFBR1 | |
| SCHEMBL8356091 | 0.86 | RIPK2 (0.74) | RIPK2SRCKDRLCKTGFBR1 | |
| SCHEMBL14811525 | 0.85 | RIPK2 (0.55) | RIPK2SRCKDRLCKTGFBR1 | |
| SCHEMBL24410875 | 0.84 | RIPK2 (0.61) | RIPK2SRCKDRLCKTGFBR1 | |
| SCHEMBL16247045 | 0.84 | RIPK2 (1.00) | RIPK2SRCKDRLCKTGFBR1 | |
| SCHEMBL8362338 | 0.83 | RIPK2 (0.64) | RIPK2SRCKDRLCKTGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5922741-A | 5-aminopyrazoles useful as tyrosine kinase inhibitors | CELLTECH THERAPEUTICS LTD. (GB) | 1999-07-13 | — | — | US | disclosed |
| EP-0906286-A1 | 5-AMINOPYRAZOLES USEFUL AS SELECTIVE INHIBITORS OF THE PROTEIN TYROSINE KINASE P56ICK | CELLTECH THERAPEUTICS LIMITED (GB) | 1999-04-07 | — | — | EP | disclosed |
| WO-1997040019-A1 | 5-AMINOPYRAZOLES USEFUL AS SELECTIVE INHIBITORS OF THE PROTEIN TYROSINE KINASE P56ICK | CELLTECH THERAPEUTICS LIMITED (GB) | 1997-10-30 | — | — | WO | disclosed |