Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 1/20 | 0.42 |
| ▸ | FEN1 | P39748 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 9/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.41 |
| ▸ | INCENP | Q9NQS7 | 3/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.40 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.40 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NOS3 | P29474 | 1/20 | 0.38 |
| ▸ | NOS1 | P29475 | 1/20 | 0.38 |
| ▸ | NOS2 | P35228 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.37 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8308612 | 0.80 | SYK (0.49) | SYKAURKBINCENPFFAR1NOS3 | |
| SCHEMBL10562958 | 0.78 | SCN8A (0.59) | SYKAURKBINCENPSCN8APARP10 | |
| SCHEMBL8308720 | 0.78 | SYK (0.51) | SYKAURKBINCENPFFAR1PARP10 | |
| SCHEMBL27096901 | 0.74 | SYK (0.51) | SYKAURKBINCENPPARP10KDM4E | |
| SCHEMBL30729929 | 0.74 | SYK (0.55) | SYKAURKBINCENPPARP10 | |
| SCHEMBL27096930 | 0.74 | SYK (0.55) | SYKAURKBINCENPPARP10 | |
| SCHEMBL20526953 | 0.74 | PARP10 (0.51) | SYKAURKBINCENPPARP10KDM4E | |
| SCHEMBL9719816 | 0.74 | MAPT (0.53) | SYKAURKBINCENPPARP10KDM4E | |
| SCHEMBL21835286 | 0.73 | SYK (0.50) | SYKAURKBINCENPFFAR1NOS3 | |
| SCHEMBL14228272 | 0.72 | SYK (0.43) | SYKAURKBINCENPSCN8APARP10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0790986-B1 | ANILINE DERIVATIVES | ZENECA LTD (GB) | 1999-01-20 | — | — | EP | disclosed |
| US-5821246-A | USEFUL AS TYROSINE KINASE INHIBITORS AND FOR THE TREATMENT OF PROLIFERATIVE DISEASES SUCH AS CANCER | ZENECA LIMITED (GB) | 1998-10-13 | — | — | US | disclosed |
| EP-0790986-A1 | ANILINE DERIVATIVES | ZENECA LIMITED (GB) | 1997-08-27 | — | — | EP | disclosed |
| WO-1996015118-A1 | ANILINE DERIVATIVES | ZENECA LIMITED (GB) | 1996-05-23 | — | — | WO | disclosed |