Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 17/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.49 |
| ▸ | INCENP | Q9NQS7 | 4/20 | 0.49 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | NOS3 | P29474 | 1/20 | 0.42 |
| ▸ | NOS1 | P29475 | 1/20 | 0.42 |
| ▸ | NOS2 | P35228 | 1/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8308720 | 0.87 | SYK (0.51) | SYKAURKBINCENPABCB1HTR1A | |
| SCHEMBL30729929 | 0.83 | SYK (0.55) | SYKAURKBINCENPABCB1HTR1A | |
| SCHEMBL27096901 | 0.83 | SYK (0.51) | SYKAURKBINCENPABCB1HTR1A | |
| SCHEMBL27096930 | 0.83 | SYK (0.55) | SYKAURKBINCENPABCB1HTR1A | |
| SCHEMBL8308610 | 0.80 | ALOX5AP (0.42) | SYKAURKBINCENPNOS3NOS1 | |
| SCHEMBL1406446 | 0.77 | SYK (0.65) | SYKAURKBINCENPABCB1HTR1A | |
| SCHEMBL21835286 | 0.76 | SYK (0.50) | SYKAURKBINCENPABCB1HTR1A | |
| SCHEMBL12301166 | 0.75 | SYK (0.62) | SYKAURKBINCENPABCB1HTR1A | |
| SCHEMBL9719784 | 0.75 | SYK (0.58) | SYKAURKBINCENPABCB1HTR1A | |
| SCHEMBL9719880 | 0.75 | SYK (0.58) | SYKAURKBINCENPABCB1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0790986-B1 | ANILINE DERIVATIVES | ZENECA LTD (GB) | 1999-01-20 | — | — | EP | disclosed |
| US-5821246-A | USEFUL AS TYROSINE KINASE INHIBITORS AND FOR THE TREATMENT OF PROLIFERATIVE DISEASES SUCH AS CANCER | ZENECA LIMITED (GB) | 1998-10-13 | — | — | US | disclosed |
| EP-0790986-A1 | ANILINE DERIVATIVES | ZENECA LIMITED (GB) | 1997-08-27 | — | — | EP | disclosed |
| WO-1996015118-A1 | ANILINE DERIVATIVES | ZENECA LIMITED (GB) | 1996-05-23 | — | — | WO | disclosed |