Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 13/20 | 0.70 |
| ▸ | CTSK | P43235 | 11/20 | 0.70 |
| ▸ | CTSB | P07858 | 4/20 | 0.67 |
| ▸ | CTSL | P07711 | 3/20 | 0.67 |
| ▸ | AKT1 | P31749 | 1/20 | 0.59 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.55 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.55 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.55 |
| ▸ | ACE | P12821 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3383006 | 0.87 | CTSS (0.77) | CTSSCTSKCTSBCTSLAKT1 | |
| SCHEMBL2440946 | 0.83 | CTSS (0.79) | CTSSCTSKCTSBCTSLAKT1 | |
| SCHEMBL10040933 | 0.83 | CTSS (0.79) | CTSSCTSKCTSBCTSLAKT1 | |
| SCHEMBL21010315 | 0.83 | CTSS (0.79) | CTSSCTSKCTSBCTSLAKT1 | |
| SCHEMBL12204485 | 0.82 | CTSS (0.77) | CTSSCTSKCTSBCTSLAKT1 | |
| SCHEMBL7724300 | 0.82 | CTSS (0.77) | CTSSCTSKCTSBCTSLAKT1 | |
| SCHEMBL7339869 | 0.82 | ACE (0.55) | CTSSCTSKCTSBCTSLAKT1 | |
| SCHEMBL7339862 | 0.82 | ACE (0.55) | CTSSCTSKCTSBCTSLAKT1 | |
| SCHEMBL14264754 | 0.81 | PSMB5 (0.59) | CTSSCTSBCTSLPSMB1PSMB5 | |
| SCHEMBL2793925 | 0.81 | CTSS (0.76) | CTSSCTSKCTSBCTSLAKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0753003-B1 | AZIRIDINE DERIVATIVES, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1999-06-16 | — | — | EP | disclosed |
| US-5668128-A | INHIBITORS OF THIOL PROTEASE, PROPHYLAXIS AND TREATMENT OF BONE DISEASES, OSTEOPOROSIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-09-16 | — | — | US | disclosed |