Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 18/20 | 0.33 |
| ▸ | RARA | P10276 | 6/20 | 0.33 |
| ▸ | RARB | P10826 | 5/20 | 0.33 |
| ▸ | RARG | P13631 | 5/20 | 0.33 |
| ▸ | RXRG | P48443 | 12/20 | 0.33 |
| ▸ | RXRB | P28702 | 8/20 | 0.33 |
| ▸ | HNF4A | P41235 | 1/20 | 0.32 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8308385 | 0.81 | RXRA (0.51) | RXRARARARARBRARGRXRG | |
| SCHEMBL8309065 | 0.81 | RXRA (0.51) | RXRARARARARBRARGRXRG | |
| SCHEMBL8308387 | 0.81 | RXRA (0.51) | RXRARARARARBRARGRXRG | |
| SCHEMBL8309070 | 0.81 | RXRA (0.51) | RXRARARARARBRARGRXRG | |
| SCHEMBL8308391 | 0.81 | RXRA (0.51) | RXRARARARARBRARGRXRG | |
| SCHEMBL8308925 | 0.78 | RXRA (0.41) | RXRARARARARBRARGRXRG | |
| SCHEMBL8320884 | 0.75 | RXRA (0.32) | RXRARARARARBRARGRXRG | |
| SCHEMBL8312185 | 0.74 | RXRA (0.32) | RXRARARARARBRARGRXRG | |
| SCHEMBL8312187 | 0.74 | RXRA (0.32) | RXRARARARARBRARGRXRG | |
| SCHEMBL8313529 | 0.73 | RXRA (0.33) | RXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0933351-A1 | Tricyclic retinoids, methods for their production and use | LIGAND PHARMACEUTICALS INCORPORATED (US) | 1999-08-04 | — | — | EP | disclosed |
| EP-0933350-A1 | Tricyclic retinoids, methods for their production and use | LIGAND PHARMACEUTICALS INCORPORATED (US) | 1999-08-04 | — | — | EP | disclosed |
| WO-1996020914-A1 | TRICYCLIC RETINOIDS, METHODS FOR THEIR PRODUCTION AND USE | LIGAND PHARMACEUTICALS INCORPORATED (US) | 1996-07-11 | — | — | WO | disclosed |