Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 5/20 | 0.45 |
| ▸ | CHUK | O15111 | 5/20 | 0.45 |
| ▸ | IKBKG | Q9Y6K9 | 4/20 | 0.45 |
| ▸ | CDK1 | P06493 | 2/20 | 0.44 |
| ▸ | CDK2 | P24941 | 2/20 | 0.44 |
| ▸ | SYK | P43405 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 10/20 | 0.43 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.42 |
| ▸ | JAK3 | P52333 | 5/20 | 0.42 |
| ▸ | AURKA | O14965 | 2/20 | 0.42 |
| ▸ | CDK7 | P50613 | 2/20 | 0.42 |
| ▸ | CDK9 | P50750 | 2/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | PAK4 | O96013 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8308363 | 0.91 | IKBKB (0.50) | IKBKBCHUKIKBKG | |
| SCHEMBL5070979 | 0.90 | IKBKB (0.47) | IKBKBCHUKIKBKGCDK1CDK2 | |
| SCHEMBL8313889 | 0.89 | IKBKB (0.44) | IKBKBCHUKIKBKGCDK1CDK2 | |
| SCHEMBL8313335 | 0.89 | IKBKB (0.49) | IKBKBCHUKIKBKGCDK1CDK2 | |
| SCHEMBL8308936 | 0.88 | CDK2 (0.47) | IKBKBCHUKIKBKGCDK1CDK2 | |
| SCHEMBL8309514 | 0.87 | JAK2 (0.45) | IKBKBCHUKIKBKGCDK1CDK2 | |
| SCHEMBL8312435 | 0.85 | IKBKB (0.51) | IKBKBCHUKIKBKGCDK1CDK2 | |
| SCHEMBL14063867 | 0.82 | JAK2 (0.46) | IKBKBCHUKIKBKGCDK1CDK2 | |
| SCHEMBL14470099 | 0.82 | IKBKB (0.44) | IKBKBCHUKCDK1CDK2JAK2 | |
| SCHEMBL8205109 | 0.80 | CDK2 (0.55) | IKBKBCHUKIKBKGCDK1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7429599-B2 | Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-09-30 | — | — | US | disclosed |
| US-7429599-B2 | Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-09-30 | — | — | US | disclosed |
| WO-2004084901-A1 | METHODS FOR TREATING OR PREVENTING AN INFLAMMATORY OR METABOLIC CONDITION BY INHIBITING JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2004-10-07 | — | — | WO | disclosed |