SCHEMBL8309015

SCHEMBL8309015

O=C1NC(=S)SC1=Cc1cccc([N+](=O)[O-])c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CRHBP P24387 1/20 1.00
CRHR2 Q13324 1/20 1.00
IGF1R P08069 1/20 0.76
MEN1 O00255 4/20 0.68
KMT2A Q03164 4/20 0.68
MAPT P10636 3/20 0.68
ALDH1A1 P00352 2/20 0.68
GAA P10253 1/20 0.68
GSK3B P49841 2/20 0.67
IDH1 O75874 1/20 0.66
NAT1 P18440 3/20 0.64
CISD1 Q9NZ45 2/20 0.64
CA2 P00918 1/20 0.61
EPHX1 P07099 1/20 0.61
POLB P06746 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8309014 1.00 CRHBP (1.00) CRHBPCRHR2IGF1RMEN1KMT2A
SCHEMBL13846818 0.86 IGF1R (1.00) CRHBPCRHR2IGF1RMEN1KMT2A
SCHEMBL1250598 0.86 IGF1R (1.00) CRHBPCRHR2IGF1RMEN1KMT2A
SCHEMBL1250596 0.86 IGF1R (1.00) CRHBPCRHR2IGF1RMEN1KMT2A
SCHEMBL6413727 0.84 IGF1R (0.76) CRHBPCRHR2IGF1RMEN1KMT2A
SCHEMBL6413731 0.84 IGF1R (0.76) CRHBPCRHR2IGF1RMEN1KMT2A
SCHEMBL15091291 0.83 CRHBP (0.71) CRHBPCRHR2GSK3BIDH1NAT1
SCHEMBL1250835 0.83 CRHBP (0.71) CRHBPCRHR2GSK3BIDH1NAT1
SCHEMBL1250831 0.83 CRHBP (0.71) CRHBPCRHR2GSK3BIDH1NAT1
SCHEMBL15097009 0.81 CRHBP (0.67) CRHBPCRHR2IGF1RMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0506876-A4 SUPER-HIGH CONTRAST SILVER HALIDE MATERIAL INT PAPER CO (US) 1994-08-10 EP claimed
EP-0506876-A1 SUPER-HIGH CONTRAST SILVER HALIDE MATERIAL INTERNATIONAL PAPER COMPANY (US) 1992-10-07 EP claimed
WO-1991009345-A1 SUPER-HIGH CONTRAST SILVER HALIDE MATERIAL INTERNATIONAL PAPER COMPANY (US) 1991-06-27 WO claimed
US-3970459-A Process for developing a direct reversal silver halide photographic light-sensitive material FUJI PHOTO FILM CO., LTD. (JA) 1976-07-20 US claimed
EP-0915090-A1 Compounds useful as hypoglycemic agents and for treating Alzheimer's disease ELI LILLY AND COMPANY (US) 1999-05-12 EP disclosed
US-5716975-A NONTOXIC RHODANINE DERIVATIVES; ANTIDIABETIC AGENTS, CATHEPSIN D INHIBITORS, B-AMYLOID PROTEIN REDUCTION ELI LILLY AND COMPANY (US) 1998-02-10 US disclosed
US-5661168-A ADMINISTERING RHODANINE DERIVATIVES TO CONTROL DIABETES ELI LILLY AND COMPANY (US) 1997-08-26 US disclosed
US-5523314-A RHODANINE DERIVATIVES ELI LILLY AND COMPANY (US) 1996-06-04 US disclosed
US-5427889-A Physical development nuclei MITSUBISHI PAPER MILLS LTD. (JP) 1995-06-27 US disclosed
EP-0506876-A4 SUPER-HIGH CONTRAST SILVER HALIDE MATERIAL INT PAPER CO (US) 1994-08-10 EP disclosed
US-5298381-A Direct positive silver halide photographic light-sensitive material FUJI PHOTO FILM CO., LTD. (JP) 1994-03-29 US disclosed
EP-0587377-A2 Thiazolidinone derivatives as hypoglycemic agents and for treating Alzheimer's disease ELI LILLY AND COMPANY (US) 1994-03-16 EP disclosed
US-4147554-A 5,6-DIHYDRO-PYRROLO(2,1-A)ISOQUINOLINES MITSUBISHI PAPER MILLS, LTD. (JP) 1979-04-03 US disclosed
US-RE29930-E HIGH SPEED EASTMAN KODAK COMPANY (US) 1979-03-13 US disclosed
US-4097285-A CYANINE DYE MITSUBISHI PAPER MILLS, LTD. (JA) 1978-06-27 US disclosed
US-RE29575-E Cubic regular grain photographic reversal emulsions EASTMAN KODAK COMPANY (US) 1978-03-14 US disclosed
US-4011081-A DIRECT-POSITIVE DOUBLE EXPOSURE PROCESS UTILIZING A PRIMITIVE, UNFOGGED SILVER HALIDE EMULSION CONTAINING AN ELECTRON ACCEPTOR EASTMAN KODAK COMPANY (US) 1977-03-08 US disclosed
US-3970461-A Fogged, direct-positive silver halide emulsion containing carbocyanine dye having indolenine nucleus FUJI PHOTO FILM CO., LTD. (JA) 1976-07-20 US disclosed
US-3970459-A Process for developing a direct reversal silver halide photographic light-sensitive material FUJI PHOTO FILM CO., LTD. (JA) 1976-07-20 US disclosed
US-3933505-A Fogged, direct positive silver halide emulsion containing a nitro-substituted fluorene desensitizer FUJI PHOTO FILM CO., LTD. (JA) 1976-01-20 US disclosed