Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.34 |
| ▸ | LPAR3 | Q9UBY5 | 2/20 | 0.34 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL233122 | 0.88 | ALDH1A1 (0.68) | TSHRCYP3A4ALDH1A1TDP1CA1 | |
| SCHEMBL15264277 | 0.86 | CYP3A4 (0.62) | TSHRCYP3A4ALDH1A1TDP1LPAR1 | |
| SCHEMBL8922109 | 0.86 | ALDH1A1 (0.75) | TSHRCYP3A4ALDH1A1TP53TDP1 | |
| SCHEMBL342779 | 0.85 | TSHR (0.72) | TSHRCYP3A4ALDH1A1TP53TDP1 | |
| SCHEMBL27042377 | 0.85 | TSHR (0.72) | TSHRCYP3A4ALDH1A1TP53TDP1 | |
| SCHEMBL8412147 | 0.83 | ALDH1A1 (0.79) | TSHRCYP3A4ALDH1A1TDP1CA1 | |
| SCHEMBL27042289 | 0.83 | TSHR (0.68) | TSHRCYP3A4ALDH1A1TP53TDP1 | |
| SCHEMBL27042152 | 0.83 | TSHR (0.68) | TSHRCYP3A4ALDH1A1TP53TDP1 | |
| SCHEMBL27042141 | 0.83 | TSHR (0.68) | TSHRCYP3A4ALDH1A1TP53TDP1 | |
| SCHEMBL4858297 | 0.83 | CYP3A4 (0.64) | TSHRCYP3A4ALDH1A1TDP1LPAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0657444-B1 | 3-Oxo-1,4-benzothiazine derivates | SANTEN PHARMACEUTICAL CO LTD (JP) | 1999-03-31 | — | — | EP | disclosed |
| US-5547952-A | TREATMENT OF CATARACTS | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1996-08-20 | — | — | US | disclosed |
| CN-1109882-A | Novel 3-oxo-1,4-benzothiazine derivatives | SANEN PHARMACEUTICAL CO LTD (JP) | 1995-10-11 | — | — | CN | disclosed |
| EP-0657444-A1 | Novel 3-oxo-1, 4-benzothiazine derivatives | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1995-06-14 | — | — | EP | disclosed |