Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 19/20 | 0.46 |
| ▸ | RXRB | P28702 | 13/20 | 0.41 |
| ▸ | RXRG | P48443 | 13/20 | 0.41 |
| ▸ | RARG | P13631 | 8/20 | 0.41 |
| ▸ | RARB | P10826 | 7/20 | 0.41 |
| ▸ | RARA | P10276 | 4/20 | 0.39 |
| ▸ | HNF4A | P41235 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8311020 | 1.00 | RXRA (0.46) | RXRARXRBRXRGRARGRARB | |
| SCHEMBL8311518 | 1.00 | RXRA (0.46) | RXRARXRBRXRGRARGRARB | |
| SCHEMBL8309723 | 1.00 | RXRA (0.46) | RXRARXRBRXRGRARGRARB | |
| SCHEMBL8309720 | 1.00 | RXRA (0.46) | RXRARXRBRXRGRARGRARB | |
| SCHEMBL8311522 | 1.00 | RXRA (0.46) | RXRARXRBRXRGRARGRARB | |
| SCHEMBL8808656 | 0.85 | RXRA (0.39) | RXRARXRBRXRGRARGRARB | |
| SCHEMBL8808653 | 0.85 | RXRA (0.39) | RXRARXRBRXRGRARGRARB | |
| SCHEMBL8309025 | 0.82 | RXRA (0.46) | RXRARXRBRXRGRARGRARB | |
| SCHEMBL8309023 | 0.82 | RXRA (0.46) | RXRARXRBRXRGRARGRARB | |
| SCHEMBL8308682 | 0.78 | RXRA (0.53) | RXRARXRBRXRGRARGRARB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0933351-A1 | Tricyclic retinoids, methods for their production and use | LIGAND PHARMACEUTICALS INCORPORATED (US) | 1999-08-04 | — | — | EP | claimed |
| WO-1996020914-A1 | TRICYCLIC RETINOIDS, METHODS FOR THEIR PRODUCTION AND USE | LIGAND PHARMACEUTICALS INCORPORATED (US) | 1996-07-11 | — | — | WO | claimed |
| EP-0933350-A1 | Tricyclic retinoids, methods for their production and use | LIGAND PHARMACEUTICALS INCORPORATED (US) | 1999-08-04 | — | — | EP | disclosed |
| EP-0933351-A1 | Tricyclic retinoids, methods for their production and use | LIGAND PHARMACEUTICALS INCORPORATED (US) | 1999-08-04 | — | — | EP | disclosed |
| EP-0800504-A1 | TRICYCLIC RETINOIDS, METHODS FOR THEIR PRODUCTION AND USE | LIGAND PHARMACEUTICALS, INC. (US) | 1997-10-15 | — | — | EP | disclosed |
| WO-1996020914-A1 | TRICYCLIC RETINOIDS, METHODS FOR THEIR PRODUCTION AND USE | LIGAND PHARMACEUTICALS INCORPORATED (US) | 1996-07-11 | — | — | WO | disclosed |