Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 19/20 | 0.53 |
| ▸ | EPHX2 | P34913 | 8/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8310300 | 1.00 | ALOX5 (0.53) | ALOX5EPHX2MEN1ALDH1A1KMT2A | |
| SCHEMBL8306855 | 0.87 | ALOX5 (0.62) | ALOX5EPHX2 | |
| SCHEMBL8305298 | 0.87 | ALOX5 (0.62) | ALOX5EPHX2 | |
| SCHEMBL8308536 | 0.78 | ALOX5 (0.77) | ALOX5EPHX2 | |
| SCHEMBL8308533 | 0.78 | ALOX5 (0.77) | ALOX5EPHX2 | |
| SCHEMBL8303774 | 0.75 | ALOX5 (0.60) | ALOX5EPHX2 | |
| SCHEMBL8303772 | 0.75 | ALOX5 (0.60) | ALOX5EPHX2 | |
| SCHEMBL8933544 | 0.71 | ALOX5 (0.72) | ALOX5EPHX2 | |
| SCHEMBL9046357 | 0.71 | ALOX5 (0.65) | ALOX5EPHX2 | |
| SCHEMBL8309411 | 0.70 | ALOX5 (0.68) | ALOX5EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0667855-B1 | SUBSTITUTED ARYLALKYNYL- AND HETEROARYLALKYNYL-N-HYDROXYUREA INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | ABBOTT LAB (US) | 1999-03-24 | — | — | EP | claimed |
| EP-0667855-B1 | SUBSTITUTED ARYLALKYNYL- AND HETEROARYLALKYNYL-N-HYDROXYUREA INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | ABBOTT LAB (US) | 1999-03-24 | — | — | EP | disclosed |
| US-5616596-A | Substituted arylalkynyl-and heteroarylalkynl-N-hydroxyurea inhibitors of leukotriene biosynthesis | ABBOTT LABORATORIES (US) | 1997-04-01 | — | — | US | disclosed |