Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 6/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 5/20 | 0.35 |
| ▸ | SCN2B | O60939 | 2/20 | 0.35 |
| ▸ | SCN1B | Q07699 | 2/20 | 0.35 |
| ▸ | SCN1A | P35498 | 1/20 | 0.35 |
| ▸ | EDNRB | P24530 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | MOGAT2 | Q3SYC2 | 2/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | TPX2 | Q9ULW0 | 1/20 | 0.32 |
| ▸ | HTR7 | P34969 | 1/20 | 0.31 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.31 |
| ▸ | CDK9 | P50750 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL831568 | 0.94 | PTGDR2 (0.36) | PTGDR2SCN9ASCN5ASCN2BSCN1B | |
| SCHEMBL832157 | 0.92 | KMT2A (0.38) | PTGDR2SCN9ASCN5ASCN2BSCN1B | |
| SCHEMBL831314 | 0.92 | SCN9A (0.36) | PTGDR2SCN9ASCN5ASCN2BSCN1B | |
| SCHEMBL8860573 | 0.92 | CYP2C9 (0.31) | SCN9ASCN5ASCN2BSCN1BSCN1A | |
| SCHEMBL831161 | 0.91 | S1PR3 (0.32) | SCN9ASCN5ASCN2BSCN1BSCN1A | |
| SCHEMBL831757 | 0.90 | PTGDR2 (0.38) | PTGDR2SCN9ASCN5ASCN2BSCN1B | |
| SCHEMBL831683 | 0.88 | CYP2C8 (0.38) | PTGDR2SCN9ASCN5ASCN2BSCN1B | |
| SCHEMBL831027 | 0.87 | PTGER3 (0.36) | EDNRBAURKATPX2 | |
| SCHEMBL862295 | 0.86 | HDAC1 (0.34) | PTGDR2SCN9ASCN5ASCN2BSCN1B | |
| SCHEMBL832279 | 0.86 | PTGDR2 (0.36) | PTGDR2SCN9ASCN5ASCN2BSCN1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143305-B2 | 2,3-substituted indole derivatives for treating viral infections | SCHERING CORPORATION (US) | 2012-03-27 | — | — | US | disclosed |
| US-8143305-B2 | 2,3-substituted indole derivatives for treating viral infections | SCHERING CORPORATION (US) | 2012-03-27 | — | — | US | disclosed |
| US-20110033417-A1 | 2,3-SUBSTITUTED INDOLE DERIVATIVES FOR TREATING VIRAL INFECTIONS | MERCK SHARP & DOHME CORP. | 2011-02-10 | — | — | US | disclosed |
| US-20110033417-A1 | 2,3-SUBSTITUTED INDOLE DERIVATIVES FOR TREATING VIRAL INFECTIONS | MERCK SHARP & DOHME CORP. | 2011-02-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110033417-A1 | 2,3-SUBSTITUTED INDOLE DERIVATIVES FOR TREATING VIRAL INFECTIONS | IDO2, IDO1, IRF3 | PTGDR2 1609/4885SCN9A 3807/4885SCN5A 1398/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.