Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 5/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 5/20 | 0.36 |
| ▸ | SCN5A | Q14524 | 4/20 | 0.36 |
| ▸ | MOGAT2 | Q3SYC2 | 3/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.36 |
| ▸ | SCN2B | O60939 | 2/20 | 0.36 |
| ▸ | SCN1B | Q07699 | 2/20 | 0.36 |
| ▸ | SCN1A | P35498 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.34 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.34 |
| ▸ | MGAT2 | Q10469 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL831314 | 0.94 | SCN9A (0.36) | PTGDR2SCN9ASCN5AMOGAT2CYP2C9 | |
| SCHEMBL831568 | 0.92 | PTGDR2 (0.36) | PTGDR2SCN9ASCN5AMOGAT2CYP2C9 | |
| SCHEMBL832286 | 0.88 | PTGDR2 (0.37) | PTGDR2CYP2C9CYP1A2CYP3A4CYP2C8 | |
| SCHEMBL831856 | 0.86 | OPRM1 (0.38) | PTGDR2RXFP1ALDH1A1 | |
| SCHEMBL832091 | 0.86 | MOGAT2 (0.35) | SCN9ASCN5AMOGAT2CYP2C9SCN2B | |
| SCHEMBL831032 | 0.86 | PTGDR2 (0.36) | PTGDR2SCN9ASCN5AMOGAT2CYP2C9 | |
| SCHEMBL832157 | 0.83 | KMT2A (0.38) | PTGDR2SCN9ASCN5AMOGAT2CYP2C9 | |
| SCHEMBL831741 | 0.82 | CYP2C8 (0.41) | PTGDR2SCN9ASCN5AMOGAT2CYP2C9 | |
| SCHEMBL831401 | 0.81 | PTGDR2 (0.38) | PTGDR2SCN9ASCN5ACYP2C9SCN2B | |
| SCHEMBL832284 | 0.81 | PTGDR2 (0.34) | PTGDR2CYP2C9CYP2C8PTGDRRXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143305-B2 | 2,3-substituted indole derivatives for treating viral infections | SCHERING CORPORATION (US) | 2012-03-27 | — | — | US | disclosed |
| US-8143305-B2 | 2,3-substituted indole derivatives for treating viral infections | SCHERING CORPORATION (US) | 2012-03-27 | — | — | US | disclosed |
| US-20110033417-A1 | 2,3-SUBSTITUTED INDOLE DERIVATIVES FOR TREATING VIRAL INFECTIONS | MERCK SHARP & DOHME CORP. | 2011-02-10 | — | — | US | disclosed |
| US-20110033417-A1 | 2,3-SUBSTITUTED INDOLE DERIVATIVES FOR TREATING VIRAL INFECTIONS | MERCK SHARP & DOHME CORP. | 2011-02-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110033417-A1 | 2,3-SUBSTITUTED INDOLE DERIVATIVES FOR TREATING VIRAL INFECTIONS | IDO2, IDO1, IRF3 | PTGDR2 1609/4885SCN9A 3807/4885SCN5A 1398/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.