Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNM1 | Q05193 | 1/20 | 0.72 |
| ▸ | NAT1 | P18440 | 6/20 | 0.69 |
| ▸ | MEN1 | O00255 | 1/20 | 0.69 |
| ▸ | NPC1 | O15118 | 1/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.69 |
| ▸ | LMNA | P02545 | 1/20 | 0.69 |
| ▸ | POLB | P06746 | 1/20 | 0.69 |
| ▸ | GAA | P10253 | 1/20 | 0.69 |
| ▸ | MAPT | P10636 | 1/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.69 |
| ▸ | CRHBP | P24387 | 2/20 | 0.68 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.68 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.68 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.68 |
| ▸ | CISD1 | Q9NZ45 | 3/20 | 0.64 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.64 |
| ▸ | MYC | P01106 | 2/20 | 0.61 |
| ▸ | MAX | P61244 | 2/20 | 0.61 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.59 |
| ▸ | CA2 | P00918 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12961160 | 1.00 | DNM1 (0.72) | DNM1NAT1MEN1NPC1ALDH1A1 | |
| SCHEMBL8310474 | 1.00 | DNM1 (0.72) | DNM1NAT1MEN1NPC1ALDH1A1 | |
| SCHEMBL14586391 | 0.87 | CISD1 (0.83) | DNM1NAT1MEN1NPC1ALDH1A1 | |
| SCHEMBL15421930 | 0.83 | PIK3CG (0.76) | DNM1NAT1MEN1NPC1ALDH1A1 | |
| SCHEMBL15421931 | 0.83 | PIK3CG (0.76) | DNM1NAT1MEN1NPC1ALDH1A1 | |
| SCHEMBL15421927 | 0.83 | PIK3CG (0.76) | DNM1NAT1MEN1NPC1ALDH1A1 | |
| SCHEMBL8308378 | 0.82 | MEN1 (1.00) | DNM1NAT1MEN1NPC1ALDH1A1 | |
| SCHEMBL8310306 | 0.82 | MEN1 (1.00) | DNM1NAT1MEN1NPC1ALDH1A1 | |
| SCHEMBL10518640 | 0.82 | CISD1 (0.73) | DNM1NAT1MEN1NPC1ALDH1A1 | |
| SCHEMBL10518639 | 0.82 | CISD1 (0.73) | DNM1NAT1MEN1NPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0915090-A1 | Compounds useful as hypoglycemic agents and for treating Alzheimer's disease | ELI LILLY AND COMPANY (US) | 1999-05-12 | — | — | EP | claimed |
| US-5716975-A | NONTOXIC RHODANINE DERIVATIVES; ANTIDIABETIC AGENTS, CATHEPSIN D INHIBITORS, B-AMYLOID PROTEIN REDUCTION | ELI LILLY AND COMPANY (US) | 1998-02-10 | — | — | US | claimed |
| US-5523314-A | RHODANINE DERIVATIVES | ELI LILLY AND COMPANY (US) | 1996-06-04 | — | — | US | claimed |
| EP-0587377-A2 | Thiazolidinone derivatives as hypoglycemic agents and for treating Alzheimer's disease | ELI LILLY AND COMPANY (US) | 1994-03-16 | — | — | EP | claimed |
| EP-0915090-A1 | Compounds useful as hypoglycemic agents and for treating Alzheimer's disease | ELI LILLY AND COMPANY (US) | 1999-05-12 | — | — | EP | disclosed |
| US-5716975-A | NONTOXIC RHODANINE DERIVATIVES; ANTIDIABETIC AGENTS, CATHEPSIN D INHIBITORS, B-AMYLOID PROTEIN REDUCTION | ELI LILLY AND COMPANY (US) | 1998-02-10 | — | — | US | disclosed |
| US-5661168-A | ADMINISTERING RHODANINE DERIVATIVES TO CONTROL DIABETES | ELI LILLY AND COMPANY (US) | 1997-08-26 | — | — | US | disclosed |
| US-5523314-A | RHODANINE DERIVATIVES | ELI LILLY AND COMPANY (US) | 1996-06-04 | — | — | US | disclosed |
| EP-0587377-A2 | Thiazolidinone derivatives as hypoglycemic agents and for treating Alzheimer's disease | ELI LILLY AND COMPANY (US) | 1994-03-16 | — | — | EP | disclosed |