Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 7/20 | 0.64 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.56 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.56 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.56 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.56 |
| ▸ | CLK1 | P49759 | 1/20 | 0.56 |
| ▸ | CLK3 | P49761 | 1/20 | 0.56 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.56 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.56 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.56 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.56 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.56 |
| ▸ | MYLK2 | Q9H1R3 | 1/20 | 0.56 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.56 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.56 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.56 |
| ▸ | NAT1 | P18440 | 4/20 | 0.56 |
| ▸ | GSK3B | P49841 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8310560 | 1.00 | PIM1 (0.64) | PIM1PIK3CDCSNK2A2PIK3CAPIK3CG | |
| SCHEMBL1250373 | 0.86 | CISD1 (0.64) | PIM1PIK3CDCSNK2A2PIK3CAPIK3CG | |
| SCHEMBL8171866 | 0.86 | PIM1 (0.46) | PIM1PIK3CDCSNK2A2PIK3CAPIK3CG | |
| SCHEMBL1250371 | 0.86 | CISD1 (0.64) | PIM1PIK3CDCSNK2A2PIK3CAPIK3CG | |
| SCHEMBL8171863 | 0.86 | PIM1 (0.46) | PIM1PIK3CDCSNK2A2PIK3CAPIK3CG | |
| SCHEMBL2065588 | 0.79 | PTP4A3 (0.64) | PIM1PIK3CDCSNK2A2PIK3CAPIK3CG | |
| SCHEMBL15304598 | 0.78 | NAT1 (0.70) | PIM1NAT1GSK3BMEN1MAPT | |
| SCHEMBL27858519 | 0.78 | NAT1 (0.70) | PIM1NAT1GSK3BMEN1MAPT | |
| SCHEMBL12892054 | 0.78 | NAT1 (0.72) | PIM1CSNK2A2CLK1CSNK2BCSNK2A1 | |
| SCHEMBL1247507 | 0.78 | PIM1 (1.00) | PIM1NAT1GSK3BMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0915090-A1 | Compounds useful as hypoglycemic agents and for treating Alzheimer's disease | ELI LILLY AND COMPANY (US) | 1999-05-12 | — | — | EP | disclosed |
| US-5716975-A | NONTOXIC RHODANINE DERIVATIVES; ANTIDIABETIC AGENTS, CATHEPSIN D INHIBITORS, B-AMYLOID PROTEIN REDUCTION | ELI LILLY AND COMPANY (US) | 1998-02-10 | — | — | US | disclosed |
| US-5661168-A | ADMINISTERING RHODANINE DERIVATIVES TO CONTROL DIABETES | ELI LILLY AND COMPANY (US) | 1997-08-26 | — | — | US | disclosed |
| US-5523314-A | RHODANINE DERIVATIVES | ELI LILLY AND COMPANY (US) | 1996-06-04 | — | — | US | disclosed |
| EP-0587377-A2 | Thiazolidinone derivatives as hypoglycemic agents and for treating Alzheimer's disease | ELI LILLY AND COMPANY (US) | 1994-03-16 | — | — | EP | disclosed |