Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN5A | Q14524 | 2/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.41 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.41 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.41 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8307197 | 0.98 | HRH3 (0.50) | SCN5AHRH3SMN1; SMN2LMNACARM1 | |
| SCHEMBL5910693 | 0.89 | HRH3 (0.57) | SCN5AHRH3SMN1; SMN2LMNACARM1 | |
| SCHEMBL8308208 | 0.86 | CARM1 (0.50) | SCN5AHRH3CARM1PRMT6PRMT8 | |
| SCHEMBL5911217 | 0.86 | HRH3 (0.62) | SCN5AHRH3SMN1; SMN2LMNACARM1 | |
| SCHEMBL17526233 | 0.86 | HRH3 (0.55) | SCN5AHRH3SMN1; SMN2LMNACARM1 | |
| SCHEMBL17526224 | 0.86 | HRH3 (0.55) | SCN5AHRH3SMN1; SMN2LMNACARM1 | |
| SCHEMBL8309995 | 0.84 | CARM1 (0.48) | SCN5AHRH3CARM1PRMT6PRMT8 | |
| SCHEMBL4381194 | 0.84 | HRH3 (0.59) | SCN5AHRH3SMN1; SMN2LMNACARM1 | |
| SCHEMBL8309186 | 0.83 | ACE2 (0.50) | SCN5AHRH3SMN1; SMN2LMNACARM1 | |
| SCHEMBL13661585 | 0.82 | HRH3 (0.56) | SCN5AHRH3SMN1; SMN2LMNACARM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0790986-B1 | ANILINE DERIVATIVES | ZENECA LTD (GB) | 1999-01-20 | — | — | EP | disclosed |
| US-5821246-A | USEFUL AS TYROSINE KINASE INHIBITORS AND FOR THE TREATMENT OF PROLIFERATIVE DISEASES SUCH AS CANCER | ZENECA LIMITED (GB) | 1998-10-13 | — | — | US | disclosed |