Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRS3 | P32247 | 13/20 | 0.55 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.41 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.41 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.41 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | EP300 | Q09472 | 1/20 | 0.38 |
| ▸ | NSD2 | O96028 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7919373 | 0.99 | BRS3 (0.56) | BRS3CSNK2A1CSNK2A2CSNK2BCSNK2A3 | |
| SCHEMBL8110596 | 0.87 | BRS3 (0.52) | BRS3HRH3NSD2 | |
| SCHEMBL7927590 | 0.87 | BRS3 (0.61) | BRS3HRH3 | |
| SCHEMBL8307560 | 0.86 | BRS3 (0.54) | BRS3CSNK2A1CSNK2A2CSNK2BCSNK2A3 | |
| Hydrochloric Acid SCHEMBL8522033 | 0.85 | BRS3 (0.53) | BRS3CSNK2A1CSNK2A2CSNK2BCSNK2A3 | |
| SCHEMBL8097344 | 0.85 | BRS3 (0.50) | BRS3CYP11B1CYP11B2HRH3NSD2 | |
| Hydrochloric Acid SCHEMBL8310064 | 0.84 | BRS3 (0.49) | BRS3CYP11B1CYP11B2HRH3NSD2 | |
| SCHEMBL7919393 | 0.84 | BRS3 (0.62) | BRS3CYP11B1CYP11B2HRH3EP300 | |
| SCHEMBL8303912 | 0.83 | BRS3 (0.55) | BRS3CYP11B1CYP11B2HRH3 | |
| Hydrochloric Acid SCHEMBL8521500 | 0.83 | BRS3 (0.61) | BRS3CYP11B1CYP11B2HRH3EP300 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0891333-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1999-01-20 | — | — | EP | disclosed |
| WO-1997036875-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1997-10-09 | — | — | WO | disclosed |