Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Fagaridine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.69 |
| ▸ | MAPT | P10636 | 6/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.69 |
| ▸ | HPGD | P15428 | 5/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.69 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.69 |
| ▸ | TP53 | P04637 | 3/20 | 0.69 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.69 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.69 |
| ▸ | RGS12 | O14924 | 2/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.69 |
| ▸ | BCHE | P06276 | 4/20 | 0.69 |
| ▸ | ACHE | P22303 | 4/20 | 0.69 |
| ▸ | MEN1 | O00255 | 4/20 | 0.69 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.69 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.69 |
| ▸ | TSHR | P16473 | 3/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fagaridine SCHEMBL6402891 | 0.99 | ALDH1A1 (0.68) | ALDH1A1MAPTSMN1; SMN2HPGDMAPK1 | |
| Fagaridine SCHEMBL8310818 | 0.96 | ALDH1A1 (0.69) | ALDH1A1MAPTSMN1; SMN2HPGDMAPK1 | |
| Fagaridine SCHEMBL108986 | 0.94 | ALDH1A1 (0.77) | ALDH1A1MAPTSMN1; SMN2HPGDMAPK1 | |
| Fagaridine SCHEMBL29369428 | 0.94 | ALDH1A1 (0.77) | ALDH1A1MAPTSMN1; SMN2HPGDMAPK1 | |
| Fagaridine SCHEMBL8711761 | 0.93 | ALDH1A1 (0.76) | ALDH1A1MAPTSMN1; SMN2HPGDMAPK1 | |
| Fagaridine SCHEMBL9547964 | 0.93 | ALDH1A1 (0.76) | ALDH1A1MAPTSMN1; SMN2HPGDMAPK1 | |
| Fagaridine SCHEMBL6961260 | 0.93 | ALDH1A1 (0.78) | ALDH1A1MAPTSMN1; SMN2HPGDMAPK1 | |
| Sulfuric Acid SCHEMBL8315897 | 0.89 | ALDH1A1 (0.66) | ALDH1A1MAPTSMN1; SMN2HPGDMAPK1 | |
| Sulfuric Acid SCHEMBL8317546 | 0.87 | TDP1 (0.52) | ALDH1A1MAPTSMN1; SMN2HPGDMAPK1 | |
| Sulfuric Acid SCHEMBL8315218 | 0.85 | TDP1 (0.51) | ALDH1A1MAPTSMN1; SMN2HPGDMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0487930-B1 | Benzo[C]phenanthridinium derivatives | NIPPON KAYAKU KK (JP) | 1999-03-24 | — | — | EP | claimed |
| US-5747502-A | ANTITUMOR AGENTS, ANTIGROWTH AGENTS AND ANTICARCINOGENIC AGENTS | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 1998-05-05 | — | — | US | claimed |
| EP-0487930-A1 | Process for preparing benzo[C]phenanthridinium derivatives, and novel compounds prepared by said process | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 1992-06-03 | — | — | EP | claimed |
| EP-0487930-B1 | Benzo[C]phenanthridinium derivatives | NIPPON KAYAKU KK (JP) | 1999-03-24 | — | — | EP | disclosed |
| US-5747502-A | ANTITUMOR AGENTS, ANTIGROWTH AGENTS AND ANTICARCINOGENIC AGENTS | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 1998-05-05 | — | — | US | disclosed |
| EP-0487930-A1 | Process for preparing benzo[C]phenanthridinium derivatives, and novel compounds prepared by said process | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 1992-06-03 | — | — | EP | disclosed |