Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP3 | P08254 | 2/20 | 0.53 |
| ▸ | MMP13 | P45452 | 2/20 | 0.53 |
| ▸ | ADAMTS5 | Q9UNA0 | 7/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.46 |
| ▸ | TLR4 | O00206 | 1/20 | 0.42 |
| ▸ | TLR2 | O60603 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.41 |
| ▸ | NSD2 | O96028 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8311449 | 1.00 | MMP3 (0.53) | MMP3MMP13ADAMTS5AKR1C3TLR4 | |
| SCHEMBL8171891 | 0.84 | MEN1 (0.53) | MMP3MMP13MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL12961165 | 0.84 | MEN1 (0.53) | MMP3MMP13MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL11451864 | 0.82 | TDP1 (0.47) | MEN1KMT2ASMN1; SMN2PSMD14NSD2 | |
| SCHEMBL11451865 | 0.82 | TDP1 (0.47) | MEN1KMT2ASMN1; SMN2PSMD14NSD2 | |
| SCHEMBL14226369 | 0.82 | MMP3 (0.41) | MMP3MMP13ADAMTS5MEN1KMT2A | |
| SCHEMBL8307760 | 0.80 | NAT1 (0.50) | MEN1KMT2ASMN1; SMN2PSMD14NSD2 | |
| SCHEMBL14226357 | 0.80 | NAT1 (0.50) | ADAMTS5HDAC8MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL1449167 | 0.80 | NAT1 (0.50) | MEN1KMT2ASMN1; SMN2PSMD14NSD2 | |
| SCHEMBL11496727 | 0.80 | MEN1 (0.44) | MMP3MMP13ADAMTS5MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0915090-A1 | Compounds useful as hypoglycemic agents and for treating Alzheimer's disease | ELI LILLY AND COMPANY (US) | 1999-05-12 | — | — | EP | disclosed |
| US-5523314-A | RHODANINE DERIVATIVES | ELI LILLY AND COMPANY (US) | 1996-06-04 | — | — | US | disclosed |
| EP-0587377-A2 | Thiazolidinone derivatives as hypoglycemic agents and for treating Alzheimer's disease | ELI LILLY AND COMPANY (US) | 1994-03-16 | — | — | EP | disclosed |