Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 20/20 | 0.67 |
| ▸ | PDE4A | P27815 | 19/20 | 0.67 |
| ▸ | PDE4B | Q07343 | 19/20 | 0.67 |
| ▸ | PDE4C | Q08493 | 19/20 | 0.67 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6950190 | 0.93 | PDE4D (0.67) | PDE4DPDE4APDE4BPDE4CPDE11A | |
| SCHEMBL7676944 | 0.88 | PDE4D (0.52) | PDE4DPDE4APDE4BPDE4CPDE11A | |
| SCHEMBL3471216 | 0.83 | PDE4D (0.61) | PDE4DPDE4APDE4BPDE4CPDE11A | |
| SCHEMBL6962814 | 0.81 | PDE4D (0.52) | PDE4DPDE4APDE4BPDE4CPDE11A | |
| SCHEMBL4755271 | 0.79 | PDE4D (1.00) | PDE4DPDE4APDE4BPDE4CPDE11A | |
| SCHEMBL8344275 | 0.77 | PDE4D (0.63) | PDE4DPDE4APDE4BPDE4CPDE11A | |
| SCHEMBL6963861 | 0.76 | PDE4D (0.75) | PDE4DPDE4APDE4BPDE4CPDE11A | |
| SCHEMBL7919048 | 0.76 | PDE4D (0.78) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL8269400 | 0.76 | PDE4D (0.64) | PDE4DPDE4APDE4BPDE4CPDE11A | |
| SCHEMBL5723087 | 0.76 | PDE4D (0.68) | PDE4DPDE4APDE4BPDE4CPDE11A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0944616-A1 | BICYCLIC ARYL CARBOXAMIDES AND THEIR THERAPEUTIC USE | Darwin Discovery Limited (GB) | 1999-09-29 | — | — | EP | claimed |
| WO-1998022460-A1 | BICYCLIC ARYL CARBOXAMIDES AND THEIR THERAPEUTIC USE | DARWIN DISCOVERY LIMITED (GB) | 1998-05-28 | — | — | WO | claimed |