Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 20/20 | 0.52 |
| ▸ | PDE4A | P27815 | 19/20 | 0.52 |
| ▸ | PDE4B | Q07343 | 19/20 | 0.52 |
| ▸ | PDE4C | Q08493 | 19/20 | 0.52 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6962814 | 0.93 | PDE4D (0.52) | PDE4DPDE4APDE4BPDE4CPDE11A | |
| SCHEMBL8311511 | 0.88 | PDE4D (0.67) | PDE4DPDE4APDE4BPDE4CPDE11A | |
| SCHEMBL8311803 | 0.84 | PDE4A (0.38) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL6950190 | 0.80 | PDE4D (0.67) | PDE4DPDE4APDE4BPDE4CPDE11A | |
| SCHEMBL12371963 | 0.74 | PDE4D (0.77) | PDE4DPDE4APDE4BPDE4CPDE11A | |
| Sch-351591 SCHEMBL157018 | 0.73 | PDE4A (0.80) | PDE4DPDE4APDE4BPDE4CPDE11A | |
| Sch-351591 SCHEMBL29378661 | 0.73 | PDE4A (0.80) | PDE4DPDE4APDE4BPDE4CPDE11A | |
| SCHEMBL8355949 | 0.73 | PDE4B (0.54) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL3471216 | 0.71 | PDE4D (0.61) | PDE4DPDE4APDE4BPDE4CPDE11A | |
| SCHEMBL14457701 | 0.71 | PDE4D (0.50) | PDE4DPDE4APDE4BPDE4CPDE11A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6353010-B1 | ENZYME INHIBITORS TUMOR NECROSIS FACTOR AND PHOSPHODIESTERASE FOR ANTIINFLAMMATORY AGENTS | DARWIN DISCOVERY, LTD. (GB) | 2002-03-05 | — | — | US | claimed |