Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 9/20 | 0.47 |
| ▸ | PDE4A | P27815 | 8/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6950187 | 0.82 | PDE4A (0.58) | MAPTSMN1; SMN2RXFP1KMT2ANPC1 | |
| SCHEMBL8315758 | 0.71 | PDE4D (0.58) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL4698806 | 0.70 | PDE4A (0.69) | MAPTSMN1; SMN2RXFP1KMT2ANPC1 | |
| SCHEMBL6957705 | 0.65 | PDE4D (1.00) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL5016484 | 0.64 | NPC1 (0.56) | MAPTSMN1; SMN2RXFP1KMT2ANPC1 | |
| SCHEMBL5022711 | 0.64 | MAPT (0.46) | MAPTSMN1; SMN2RXFP1KMT2ANPC1 | |
| SCHEMBL5546551 | 0.63 | MAPT (0.48) | MAPTSMN1; SMN2RXFP1KMT2ANPC1 | |
| SCHEMBL5022909 | 0.63 | KMT2A (0.55) | MAPTSMN1; SMN2RXFP1KMT2ANPC1 | |
| SCHEMBL6954457 | 0.63 | PDE4D (1.00) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL1553355 | 0.63 | PDE4D (1.00) | PDE4BPDE4APDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0944616-A1 | BICYCLIC ARYL CARBOXAMIDES AND THEIR THERAPEUTIC USE | Darwin Discovery Limited (GB) | 1999-09-29 | — | — | EP | disclosed |
| WO-1998022460-A1 | BICYCLIC ARYL CARBOXAMIDES AND THEIR THERAPEUTIC USE | DARWIN DISCOVERY LIMITED (GB) | 1998-05-28 | — | — | WO | disclosed |