Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9052325 | 0.79 | OPRM1 (0.58) | OPRM1KMT2AMEN1 | |
| SCHEMBL15969314 | 0.77 | SMN1; SMN2 (0.40) | PDK2ALDH1A1TP53MAPT | |
| SCHEMBL2802804 | 0.77 | HRH3 (0.55) | THRBTDP1OPRM1ALDH1A1 | |
| SCHEMBL4979700 | 0.76 | OPRM1 (0.54) | OPRM1KMT2AMEN1 | |
| SCHEMBL2801416 | 0.76 | OPRM1 (0.41) | OPRM1KMT2AALDH1A1MEN1USP2 | |
| SCHEMBL2315258 | 0.76 | OPRM1 (0.54) | OPRM1KMT2AMEN1 | |
| SCHEMBL4365551 | 0.74 | NPY5R (0.58) | ALDH1A1 | |
| SCHEMBL2803156 | 0.74 | MEN1 (0.37) | KMT2AALDH1A1TSHRMEN1USP2 | |
| SCHEMBL4365548 | 0.74 | NPY5R (0.58) | ALDH1A1 | |
| SCHEMBL23647576 | 0.73 | HDAC4 (0.42) | OPRM1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0662481-B1 | Spiro piperidines and homologs promote release of growth hormone | MERCK & CO INC (US) | 1999-03-24 | — | — | EP | disclosed |
| US-5578593-A | RELEASING GROWTH HORMONES FOR ANIMALS | MERCK & CO., INC. (US) | 1996-11-26 | — | — | US | disclosed |
| EP-0662481-A1 | Spiro piperidines and homologs promote release of growth hormone | MERCK & CO. INC. (US) | 1995-07-12 | — | — | EP | disclosed |