Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 2/20 | 0.62 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | PYGL | P06737 | 1/20 | 0.49 |
| ▸ | PLK1 | P53350 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.47 |
| ▸ | IDH1 | O75874 | 1/20 | 0.47 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL761366 | 0.81 | PLAU (0.66) | PLAUPLK1HDAC8HDAC6HDAC2 | |
| SCHEMBL6640227 | 0.81 | PLAU (0.66) | PLAUPLK1HPGDTSHRHTT | |
| SCHEMBL3033752 | 0.81 | HDAC6 (0.73) | PLAUPLK1HPGDTSHRHTT | |
| SCHEMBL30369626 | 0.81 | PLAU (0.66) | PLAUPLK1HDAC8HDAC6HDAC2 | |
| SCHEMBL79445 | 0.80 | HDAC2 (0.64) | ALOX15PLK1HPGDTSHRHTT | |
| SCHEMBL3028425 | 0.79 | PLAU (0.74) | PLAUPLK1HPGDTSHRHTT | |
| SCHEMBL16302072 | 0.79 | PLAU (0.64) | PLAUPLK1HPGDTSHRHTT | |
| SCHEMBL16811740 | 0.79 | PLAU (0.64) | PLAUPLK1HPGDTSHRHTT | |
| SCHEMBL11662765 | 0.79 | CYP2A6 (0.55) | HPGDHTTSMN1; SMN2NPC1KMT2A | |
| Bromide SCHEMBL4749650 | 0.78 | PLAU (0.57) | PLAUALOX15PLK1HPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020257487-A1 | GLYCOLATE OXIDASE INHIBITORS FOR THE TREATMENT OF DISEASE | BIOMARIN PHARMACEUTICAL INC. (US) | 2020-12-24 | — | — | WO | disclosed |
| WO-2004082687-A1 | LACTAM-CONTAINING CYCLIC DIAMINES AND DERIVATIVES AS FACTOR XA INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-09-30 | — | — | WO | disclosed |