SCHEMBL79445

SCHEMBL79445

CNC(=O)c1ccc(Cl)cc1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC2 Q92769 1/20 0.64
HDAC8 Q9BY41 1/20 0.64
HDAC6 Q9UBN7 1/20 0.64
ALDH1A1 P00352 3/20 0.61
KDM4E B2RXH2 1/20 0.61
LMNA P02545 1/20 0.61
MAPT P10636 1/20 0.61
L3MBTL1 Q9Y468 1/20 0.61
HTT P42858 2/20 0.59
TSHR P16473 2/20 0.59
HPGD P15428 1/20 0.59
SMN1; SMN2 Q16637 1/20 0.59
PLK1 P53350 4/20 0.57
POLB P06746 2/20 0.57
PTGS2 P35354 1/20 0.55
TDP1 Q9NUW8 1/20 0.55
NPC1 O15118 1/20 0.54
CES2 O00748 1/20 0.54
CES1 P23141 1/20 0.54
CA2 P00918 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1132053 0.94 HDAC2 (0.57) HDAC2HDAC8HDAC6ALDH1A1KDM4E
SCHEMBL28680084 0.87 ALDH1A1 (0.55) HDAC2HDAC8HDAC6ALDH1A1KDM4E
SCHEMBL250247 0.87 HDAC6 (0.80) HDAC2HDAC8HDAC6ALDH1A1HTT
SCHEMBL15047786 0.85 MAPT (0.67) ALDH1A1KDM4ELMNAMAPTL3MBTL1
SCHEMBL13273458 0.82 ALDH1A1 (0.57) ALDH1A1KDM4ELMNAMAPTL3MBTL1
SCHEMBL7042272 0.82 POLB (0.63) HDAC2ALDH1A1KDM4ELMNAMAPT
SCHEMBL3912992 0.81 POLB (0.62) HDAC2ALDH1A1KDM4ELMNAMAPT
SCHEMBL28959084 0.81 MAPT (0.61) ALDH1A1KDM4ELMNAMAPTL3MBTL1
SCHEMBL15545731 0.81 HDAC8 (0.64) HDAC2HDAC8HDAC6ALDH1A1HTT
SCHEMBL16198923 0.80 HDAC6 (0.70) HDAC2HDAC8HDAC6HTTTSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 287 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2097379-A1 CARBOXAMIDE DERIVATIVES AS ION CHANNEL MODULATORS Wyeth a Corporation of the State of Delaware (US) 2009-09-09 EP claimed
WO-2008073936-A1 CARBOXAMIDE DERIVATIVES AS ION CHANNEL MODULATORS WYETH (US) 2008-06-19 WO claimed
CN-120004754-A Preparation method of high-purity N-methyl halogenated benzamide 福州大学 2025-05-16 CN disclosed
WO-2025073702-A1 PROCESS FOR PREPARING AROMATIC AMINES FROM ARYL CHLORIDES BASF SE (DE) 2025-04-10 WO disclosed
WO-2024086767-A2 GLYCAN CONJUGATE COMPOSITIONS AND METHODS GANNA BIO, INC. (US) 2024-04-25 WO disclosed
US-20230301984-A1 CYCLIC COMPOUNDS FOR USE IN TREATING RETINAL DEGENERATION THE USA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2023-09-28 US disclosed
WO-2023144450-A1 COMPOUNDS FOR USE IN THE TREATMENT OF CANCER AND INFLAMMATORY CONDITIONS OULUN YLIOPISTO (FI) 2023-08-03 WO disclosed
US-20230203030-A1 COMPOUNDS AND METHODS FOR THE ENHANCED DEGRADATION OF TARGETED PROTEINS ARVINAS OPERATIONS, INC. 2023-06-29 US disclosed
CN-107162928-B Halogenated analogs of anti-fibrotic agents 塞尔塔医疗有限公司 2022-03-11 CN disclosed
US-20210355135-A1 P38ALPHA MITOGEN-ACTIVATED PROTEIN KINASE INHIBITORS GEN1E LIFESCIENCES INC. 2021-11-18 US disclosed
EP-2772480-B2 HIV REPLICATION INHIBITOR SHIONOGI & CO (JP) 2020-12-09 EP disclosed
US-4097489-A PROSTAGLANDINS THE UPJOHN COMPANY (US) 1978-06-27 US disclosed
US-4052382-A 1-PHENYL-3-AZACARBOCYCLIC-UREAS STERLING DRUG INC. (US) 1977-10-04 US disclosed
US-4028381-A ANTIANXIETY AND ANTIDEPRESSANT AGENTS CIBA-GEIGY CORPORATION (US) 1977-06-07 US disclosed
US-4026938-A 1-Phenyl-3-azacarbocyclic-ureas STERLING DRUG INC. (US) 1977-05-31 US disclosed
US-4022801-A ANTIANXIETY AND ANTIDEPRESSANTS CIBA-GEIGY CORPORATION (US) 1977-05-10 US disclosed
US-4022800-A ANTIANXIETY AND ANTIDEPRESSANTS CIBA-GEIGY CORPORATION (US) 1977-05-10 US disclosed
US-3963748-A 1-Phenyl-3-azacarbocyclic-ureas STERLING DRUG INC. (US) 1976-06-15 US disclosed
US-3959269-A TRANQUILIZERS, SEDATIVES SANDOZ, INC. (US) 1976-05-25 US disclosed
US-3944570-A ANTIINFLAMMATORY SANDOZ, INC. (US) 1976-03-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210355135-A1 P38ALPHA MITOGEN-ACTIVATED PROTEIN KINASE INHIBITORS MAPKAPK2, MAPK1, MAPK8 HDAC2 1728/4885HDAC8 643/4885HDAC6 558/4885
US-20230301984-A1 CYCLIC COMPOUNDS FOR USE IN TREATING RETINAL DEGENERATION ALDH1A2, PDE6D, PDE6C HDAC2 263/4885HDAC8 95/4885HDAC6 402/4885
US-20230203030-A1 COMPOUNDS AND METHODS FOR THE ENHANCED DEGRADATION OF TARGETED PROTEINS VHL, MDM2, XIAP HDAC2 1969/4885HDAC8 2117/4885HDAC6 363/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.