Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 2/20 | 0.73 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.73 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.72 |
| ▸ | NAT1 | P18440 | 5/20 | 0.72 |
| ▸ | CISD1 | Q9NZ45 | 2/20 | 0.72 |
| ▸ | ADAMTS5 | Q9UNA0 | 3/20 | 0.70 |
| ▸ | MYC | P01106 | 2/20 | 0.70 |
| ▸ | MAX | P61244 | 2/20 | 0.70 |
| ▸ | CA2 | P00918 | 1/20 | 0.69 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.69 |
| ▸ | CRHBP | P24387 | 2/20 | 0.65 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.65 |
| ▸ | MMP3 | P08254 | 1/20 | 0.65 |
| ▸ | MMP13 | P45452 | 1/20 | 0.65 |
| ▸ | PTP4A3 | O75365 | 1/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | RAB9A | P51151 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8312151 | 1.00 | PIM1 (0.73) | PIM1PIM2DNM1NAT1CISD1 | |
| SCHEMBL1250348 | 0.84 | PIM1 (1.00) | PIM1PIM2CISD1ADAMTS5 | |
| SCHEMBL2548389 | 0.84 | PIM1 (1.00) | PIM1PIM2CISD1ADAMTS5 | |
| SCHEMBL1250346 | 0.84 | PIM1 (1.00) | PIM1PIM2CISD1ADAMTS5 | |
| SCHEMBL10519622 | 0.84 | PIM1 (0.74) | PIM1PIM2NAT1CISD1MYC | |
| SCHEMBL7562040 | 0.84 | CISD1 (1.00) | PIM1PIM2NAT1CISD1MYC | |
| SCHEMBL7557609 | 0.84 | NAT1 (1.00) | PIM1PIM2NAT1CISD1ADAMTS5 | |
| SCHEMBL12892064 | 0.84 | NAT1 (1.00) | NAT1CISD1ADAMTS5MYCMAX | |
| SCHEMBL8310946 | 0.84 | NAT1 (1.00) | NAT1CISD1ADAMTS5MYCMAX | |
| SCHEMBL10519629 | 0.84 | PIM1 (0.74) | PIM1PIM2NAT1CISD1MYC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0915090-A1 | Compounds useful as hypoglycemic agents and for treating Alzheimer's disease | ELI LILLY AND COMPANY (US) | 1999-05-12 | — | — | EP | disclosed |
| US-5716975-A | NONTOXIC RHODANINE DERIVATIVES; ANTIDIABETIC AGENTS, CATHEPSIN D INHIBITORS, B-AMYLOID PROTEIN REDUCTION | ELI LILLY AND COMPANY (US) | 1998-02-10 | — | — | US | disclosed |
| US-5661168-A | ADMINISTERING RHODANINE DERIVATIVES TO CONTROL DIABETES | ELI LILLY AND COMPANY (US) | 1997-08-26 | — | — | US | disclosed |
| US-5523314-A | RHODANINE DERIVATIVES | ELI LILLY AND COMPANY (US) | 1996-06-04 | — | — | US | disclosed |
| CN-1091006-A | Chemical compound as blood sugar lowering and treatment degenerative brain disorder | LILLY CO ELI (US) | 1994-08-24 | — | — | CN | disclosed |
| EP-0587377-A2 | Thiazolidinone derivatives as hypoglycemic agents and for treating Alzheimer's disease | ELI LILLY AND COMPANY (US) | 1994-03-16 | — | — | EP | disclosed |