Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAT1 | P18440 | 4/20 | 1.00 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.74 |
| ▸ | CISD1 | Q9NZ45 | 4/20 | 0.70 |
| ▸ | CA2 | P00918 | 1/20 | 0.68 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.68 |
| ▸ | MYC | P01106 | 1/20 | 0.68 |
| ▸ | MAX | P61244 | 1/20 | 0.68 |
| ▸ | MMP13 | P45452 | 2/20 | 0.67 |
| ▸ | MMP3 | P08254 | 1/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.66 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.64 |
| ▸ | CRHBP | P24387 | 1/20 | 0.64 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.64 |
| ▸ | GSK3B | P49841 | 1/20 | 0.63 |
| ▸ | MAOA | P21397 | 1/20 | 0.62 |
| ▸ | MAOB | P27338 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12892064 | 1.00 | NAT1 (1.00) | NAT1AKR1B1CISD1CA2EPHX1 | |
| SCHEMBL8310945 | 1.00 | NAT1 (1.00) | NAT1AKR1B1CISD1CA2EPHX1 | |
| SCHEMBL18103005 | 0.92 | NAT1 (0.85) | NAT1AKR1B1CISD1CA2EPHX1 | |
| SCHEMBL18103051 | 0.91 | NAT1 (0.83) | NAT1AKR1B1MMP13MMP3ADAMTS5 | |
| SCHEMBL18103002 | 0.85 | NAT1 (0.74) | NAT1AKR1B1CISD1CA2EPHX1 | |
| SCHEMBL18103006 | 0.85 | NAT1 (0.74) | NAT1AKR1B1CISD1CA2EPHX1 | |
| SCHEMBL12259747 | 0.85 | AKR1B1 (1.00) | NAT1AKR1B1CISD1TDP1GSK3B | |
| SCHEMBL18103062 | 0.85 | MMP13 (0.82) | NAT1AKR1B1MMP13MMP3ADAMTS5 | |
| SCHEMBL18103055 | 0.85 | MMP3 (0.75) | NAT1AKR1B1MMP13MMP3ADAMTS5 | |
| SCHEMBL15421927 | 0.84 | PIK3CG (0.76) | NAT1CISD1CA2EPHX1MYC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0915090-A1 | Compounds useful as hypoglycemic agents and for treating Alzheimer's disease | ELI LILLY AND COMPANY (US) | 1999-05-12 | — | — | EP | disclosed |
| US-5716975-A | NONTOXIC RHODANINE DERIVATIVES; ANTIDIABETIC AGENTS, CATHEPSIN D INHIBITORS, B-AMYLOID PROTEIN REDUCTION | ELI LILLY AND COMPANY (US) | 1998-02-10 | — | — | US | disclosed |
| US-5661168-A | ADMINISTERING RHODANINE DERIVATIVES TO CONTROL DIABETES | ELI LILLY AND COMPANY (US) | 1997-08-26 | — | — | US | disclosed |
| US-5523314-A | RHODANINE DERIVATIVES | ELI LILLY AND COMPANY (US) | 1996-06-04 | — | — | US | disclosed |
| CN-1091006-A | Chemical compound as blood sugar lowering and treatment degenerative brain disorder | LILLY CO ELI (US) | 1994-08-24 | — | — | CN | disclosed |
| EP-0587377-A2 | Thiazolidinone derivatives as hypoglycemic agents and for treating Alzheimer's disease | ELI LILLY AND COMPANY (US) | 1994-03-16 | — | — | EP | disclosed |