Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lycetamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 known ✓ | P21453 | 2/20 | 0.43 |
| ▸ | S1PR5 known ✓ | Q9H228 | 1/20 | 0.43 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.74 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.74 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.74 |
| ▸ | RRM1 | P23921 | 1/20 | 0.61 |
| ▸ | DPP7 | Q9UHL4 | 3/20 | 0.59 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.56 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.51 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.51 |
| ▸ | GSR | P00390 | 1/20 | 0.48 |
| ▸ | TLR2 | O60603 | 6/20 | 0.47 |
| ▸ | S1PR2 | O95136 | 2/20 | 0.43 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.43 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.43 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Octadecylamine SCHEMBL21055685 | 0.93 | GNAI3 (0.59) | GNAI3GNAO1GNAI1RRM1DPP7 | |
| Octadecylamine SCHEMBL21055684 | 0.93 | GNAI3 (0.59) | GNAI3GNAO1GNAI1RRM1DPP7 | |
| SCHEMBL24420660 | 0.89 | DPP7 (0.73) | GNAI3GNAO1GNAI1RRM1DPP7 | |
| SCHEMBL27115127 | 0.89 | DPP7 (0.73) | GNAI3GNAO1GNAI1RRM1DPP7 | |
| Lycetamine SCHEMBL15367599 | 0.87 | GNAI3 (0.91) | GNAI3GNAO1GNAI1RRM1DPP7 | |
| SCHEMBL19362563 | 0.87 | GNAI3 (0.66) | GNAI3GNAO1GNAI1RRM1DPP7 | |
| SCHEMBL6037849 | 0.87 | DPP7 (0.53) | GNAI3GNAO1GNAI1RRM1DPP7 | |
| SCHEMBL27114206 | 0.87 | DPP7 (0.76) | GNAI3GNAO1GNAI1RRM1DPP7 | |
| SCHEMBL6037862 | 0.87 | DPP7 (0.53) | GNAI3GNAO1GNAI1RRM1DPP7 | |
| Arginine SCHEMBL6242106 | 0.87 | DPP7 (0.53) | GNAI3GNAO1GNAI1RRM1DPP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143372-B2 | Synthetic regulators of ferritin protein nanocage pores and methods of use thereof | CHILDREN'S HOSPITAL & RESEARCH CENTER OAKLAND (US) | 2012-03-27 | — | — | US | disclosed |
| US-20090325869-A1 | SYNTHETIC REGULATORS OF FERRITIN PROTEIN NANOCAGE PORES AND METHODS OF USE THEREOF | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2009-12-31 | — | — | US | disclosed |