Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 14/20 | 0.54 |
| ▸ | CHUK | O15111 | 11/20 | 0.54 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.49 |
| ▸ | CDK2 | P24941 | 1/20 | 0.49 |
| ▸ | MYLK4 | Q86YV6 | 1/20 | 0.48 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.48 |
| ▸ | MTOR | P42345 | 1/20 | 0.48 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.48 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.47 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.47 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8312171 | 0.89 | IKBKB (0.54) | IKBKBCHUKCCNE1CDK2MTOR | |
| SCHEMBL8312348 | 0.88 | MTOR (0.48) | IKBKBCHUKCDK2MYLK4STK17A | |
| SCHEMBL8312297 | 0.86 | IKBKB (0.64) | IKBKBCHUKCCNE1CDK2MAPK8 | |
| SCHEMBL14021585 | 0.86 | CDK1 (0.53) | IKBKBCHUKCDK2MYLK4STK17A | |
| SCHEMBL8312855 | 0.85 | IKBKB (0.59) | IKBKBCHUKCCNE1CDK2MAPK8 | |
| SCHEMBL8314752 | 0.85 | IKBKB (0.55) | IKBKBCHUKCCNE1CDK2MAPK8 | |
| SCHEMBL14021233 | 0.84 | CDK1 (0.49) | IKBKBCHUKCDK2MYLK4STK17A | |
| SCHEMBL8312856 | 0.84 | IKBKB (0.57) | IKBKBCHUKCCNE1CDK2MAPK8 | |
| SCHEMBL8309279 | 0.84 | IKBKB (0.59) | IKBKBCHUKCCNE1CDK2MAPK8 | |
| SCHEMBL8315439 | 0.84 | IKBKB (0.54) | IKBKBCHUKCCNE1CDK2MAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7429599-B2 | Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-09-30 | — | — | US | disclosed |
| US-7429599-B2 | Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-09-30 | — | — | US | disclosed |
| WO-2004084901-A1 | METHODS FOR TREATING OR PREVENTING AN INFLAMMATORY OR METABOLIC CONDITION BY INHIBITING JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2004-10-07 | — | — | WO | disclosed |