Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.60 |
| ▸ | PKM | P14618 | 3/20 | 0.60 |
| ▸ | LMNA | P02545 | 5/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.53 |
| ▸ | ABL1 | P00519 | 2/20 | 0.50 |
| ▸ | BCR | P11274 | 2/20 | 0.50 |
| ▸ | USP2 | O75604 | 2/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | MTOR | P42345 | 1/20 | 0.50 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.50 |
| ▸ | IKBKB | O14920 | 2/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8311370 | 0.90 | MTOR (0.52) | ALDH1A1LMNASMN1; SMN2HTTMTOR | |
| SCHEMBL14021344 | 0.89 | BRAF (0.55) | ALDH1A1PKMMTORSMG1IKBKB | |
| SCHEMBL4062111 | 0.89 | IKBKB (0.52) | LMNASMN1; SMN2USP2ALOX15HTT | |
| SCHEMBL8311593 | 0.87 | ABL1 (0.53) | ALDH1A1LMNAABL1BCRMTOR | |
| SCHEMBL14071746 | 0.87 | MTOR (0.49) | ALDH1A1PKMLMNASMN1; SMN2GAA | |
| SCHEMBL14063812 | 0.86 | MTOR (0.51) | ALDH1A1PKMABL1BCRMTOR | |
| SCHEMBL8308563 | 0.86 | IKBKB (0.54) | LMNASMN1; SMN2GAAHTTMTOR | |
| SCHEMBL8311025 | 0.84 | HTT (0.58) | ALDH1A1PKMLMNASMN1; SMN2HTT | |
| SCHEMBL14063805 | 0.84 | IKBKB (0.54) | LMNASMN1; SMN2HTTMTORSMG1 | |
| SCHEMBL14063902 | 0.84 | IKBKB (0.54) | LMNASMN1; SMN2HTTMTORSMG1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7429599-B2 | Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-09-30 | — | — | US | disclosed |
| US-7429599-B2 | Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-09-30 | — | — | US | disclosed |
| WO-2004084901-A1 | METHODS FOR TREATING OR PREVENTING AN INFLAMMATORY OR METABOLIC CONDITION BY INHIBITING JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2004-10-07 | — | — | WO | disclosed |