Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 1/20 | 0.52 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.52 |
| ▸ | IKBKB | O14920 | 4/20 | 0.49 |
| ▸ | CHUK | O15111 | 3/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | SYK | P43405 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | BRAF | P15056 | 3/20 | 0.47 |
| ▸ | EIF2AK3 | Q9NZJ5 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CDK1 | P06493 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
| ▸ | IKBKG | Q9Y6K9 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14021344 | 0.91 | BRAF (0.55) | MTORSMG1IKBKBCHUKALDH1A1 | |
| SCHEMBL4062111 | 0.91 | IKBKB (0.52) | MTORSMG1IKBKBCHUKHTT | |
| SCHEMBL8311025 | 0.90 | HTT (0.58) | MTORSMG1IKBKBCHUKHTT | |
| SCHEMBL8312176 | 0.90 | ALDH1A1 (0.60) | MTORSMG1IKBKBCHUKHTT | |
| SCHEMBL8311593 | 0.89 | ABL1 (0.53) | MTORSMG1IKBKBCHUKALDH1A1 | |
| SCHEMBL14071746 | 0.89 | MTOR (0.49) | MTORSMG1IKBKBCHUKHTT | |
| SCHEMBL14063812 | 0.88 | MTOR (0.51) | MTORSMG1IKBKBCHUKALDH1A1 | |
| SCHEMBL8308563 | 0.88 | IKBKB (0.54) | MTORSMG1IKBKBCHUKHTT | |
| SCHEMBL14063902 | 0.86 | IKBKB (0.54) | MTORSMG1IKBKBCHUKHTT | |
| SCHEMBL14063805 | 0.86 | IKBKB (0.54) | MTORSMG1IKBKBCHUKHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7429599-B2 | Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-09-30 | — | — | US | disclosed |
| US-7429599-B2 | Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-09-30 | — | — | US | disclosed |
| WO-2004084901-A1 | METHODS FOR TREATING OR PREVENTING AN INFLAMMATORY OR METABOLIC CONDITION BY INHIBITING JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2004-10-07 | — | — | WO | disclosed |