Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 19/20 | 0.52 |
| ▸ | PDE4C | Q08493 | 16/20 | 0.52 |
| ▸ | PDE4A | P27815 | 10/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 10/20 | 0.52 |
| ▸ | HTR2B | P41595 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3393582 | 0.91 | PDE4B (0.52) | PDE4BPDE4CPDE4APDE4DHTR2B | |
| SCHEMBL10325822 | 0.91 | PDE4B (0.52) | PDE4BPDE4CPDE4APDE4DHTR2B | |
| SCHEMBL5514803 | 0.91 | PDE4B (0.52) | PDE4BPDE4CPDE4APDE4DHTR2B | |
| SCHEMBL5509206 | 0.91 | PDE4B (0.52) | PDE4BPDE4CPDE4APDE4DHTR2B | |
| SCHEMBL5510495 | 0.91 | PDE4B (0.52) | PDE4BPDE4CPDE4APDE4DHTR2B | |
| Dovramilast SCHEMBL15869347 | 0.87 | PDE4B (0.56) | PDE4BPDE4CPDE4APDE4DHTR2B | |
| Dovramilast SCHEMBL14983202 | 0.86 | PDE4B (0.59) | PDE4BPDE4CPDE4APDE4DHTR2B | |
| Dovramilast SCHEMBL29366888 | 0.86 | PDE4B (0.59) | PDE4BPDE4CPDE4APDE4DHTR2B | |
| Dovramilast SCHEMBL673303 | 0.86 | PDE4B (0.59) | PDE4BPDE4CPDE4APDE4DHTR2B | |
| Dovramilast SCHEMBL30701938 | 0.86 | PDE4B (0.59) | PDE4BPDE4CPDE4APDE4DHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004080423-A2 | 7-AMINO- ISOINDOLYL COMPOUNDS AMD THEIR PHARMACEUTICAL USES | CELGENE CORPORATION (US) | 2004-09-23 | — | — | WO | disclosed |