SCHEMBL8312205

SCHEMBL8312205

NC1CCN(c2cncc(Br)c2)CC1

nearest known ligand 0.57

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 9/20 0.57
CHRNA4 P43681 9/20 0.57
CHRNB4 P30926 6/20 0.55
CHRNA3 P32297 6/20 0.55
SSTR2 P30874 1/20 0.44
SMYD3 Q9H7B4 1/20 0.42
PIM1 P11309 3/20 0.41
ADAMTS5 Q9UNA0 1/20 0.37
VCP P55072 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21625650 0.90 CHRNB2 (0.59) CHRNB2CHRNA4CHRNB4CHRNA3SSTR2
SCHEMBL21625651 0.90 CHRNB2 (0.59) CHRNB2CHRNA4CHRNB4CHRNA3SSTR2
SCHEMBL27461278 0.83 CHRNB2 (0.57) CHRNB2CHRNA4CHRNB4CHRNA3ADAMTS5
SCHEMBL30381538 0.83 CHRNB2 (0.57) CHRNB2CHRNA4CHRNB4CHRNA3ADAMTS5
SCHEMBL30811747 0.81 CHRNB2 (0.61) CHRNB2CHRNA4CHRNB4CHRNA3
SCHEMBL30665753 0.80 CHRNB2 (0.77) CHRNB2CHRNA4CHRNB4CHRNA3ADAMTS5
SCHEMBL1980777 0.80 CHRNB2 (0.77) CHRNB2CHRNA4CHRNB4CHRNA3
SCHEMBL2067959 0.80 CHRNB2 (0.77) CHRNB2CHRNA4CHRNB4CHRNA3ADAMTS5
SCHEMBL25074515 0.79 CHRNB2 (0.56) CHRNB2CHRNA4CHRNB4CHRNA3ADAMTS5
SCHEMBL19947418 0.79 CHRNB2 (0.53) CHRNB2CHRNA4CHRNB4CHRNA3ADAMTS5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2005019200-A2 ARYL PIPERIDINE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF ICOS CORPORATION (US) 2005-03-03 WO disclosed